Bu-Zhong-Yi-Qi pill alleviate the chemotherapy-related fatigue in 4 T1 murine breast cancer model

BMC Complementary and Alternative Medicine

Research Article

Keqiang Yu¹  Wei Tan²  JingRu Cheng³  Ying Huang³  Ren Luo³  Xiaoshan Zhao³  Ya Xiao³  Yanyan Liu⁴  Mingzi Ouyang⁴  Xiaomin Sun⁵ 

[1] Department of Personnel Section, Southern Medical University, 510515, Guangdong, Guangzhou, China;Department of Traditional Chinese Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, 510080, Guangzhou, Guangdong, China;Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, 510515, Guangdong, Guangzhou, China;School of Traditional Chinese Medicine, Southern Medical University, 510515, Guangdong, Guangzhou, China;Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, 510515, Guangdong, Guangzhou, China;School of Traditional Chinese Medicine, Southern Medical University, 510515, Guangdong, Guangzhou, China;The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 510405, Guangzhou, China;School of Traditional Chinese Medicine, Southern Medical University, 510515, Guangdong, Guangzhou, China;

关键词: Paclitaxel;    Chronic Fatigue Syndrome;    Normal Control Group;    Swimming Time;    Average Survival Time;   

DOI  :  10.1186/1472-6882-14-497

 received in 2013-03-14, accepted in 2014-12-10,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundPaclitaxel induced fatigue still remains underrecognized and undertreated, partly because of limited understanding of its pathophysiology and lack of effective treatments. This study is aim to evaluate the anti-fatigue effects and mechanism of Bu-Zhong-Yi-Qi pill in murine 4 T1 breast cancer mice were treated with paclitaxel.MethodsBreast cancer mice established with murine 4 T1 cells were randomly and repectively divided into five groups: negative control group (NC), tumor control group (TC), paclitaxel group (PTX), Bu-Zhong-Yi-Qi pill group (BZYQ) and Bu-Zhong-Yi-Qi pill plus paclitaxel group (BZYQ + PTX). The mice were administered for 21 days. During this period, the tumor volume, body weight and the weight-loaded swimming time were measured. After the last administration, all mice were sacrificed, weighted the tumor, measured immune cell cytokines and oxidative stress indicator. The remaining 10 mice in each group were observed for survival analysis.ResultsTreatments with BZYQ + PTX and PTX significantly reduced the rates of tumor volume in comparison with TC starting on the 9th day and the 18th day respectively (P < 0.05-0.01), and presented decreased tumor weight compared to TC (P < 0.05-0.01). Compared with mice in TC group, the median survival time and the average survival time in BZYQ + PTX group, BZYQ group and PTX group were significantly prolonged (P < 0.05-0.01). The swimming time of the BZYQ + PTX group gradually increased, which is longer than the PTX group on Day 14 and Day 21 (P < 0.01). The level of TNF-α was lower in BZYQ + PTX group than PTX group (P < 0.01). The level of SOD activity in BZYQ + PTX group was lower than the NC group (P <0.01), but much higher than the PTX group (P < 0.01). The level of MDA of BZYQ + PTX group was higher than the NC group (P < 0.01), but significant lower than the PTX group (P < 0.01).ConclusionsBZYQ has the potential of alleviating paclitaxel chemotherapy-related fatigue in 4 T1 breast cancer mice by reducing the serum levels of TNF-α and modulating the level of MDA and the SOD activity.

【 授权许可】

Unknown   
© Ouyang et al.; licensee BioMed Central. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.