Plasma concentrations of soluble cytokine receptors in euthymic bipolar patients with and without subsyndromal symptoms

BMC Psychiatry

Research Article

Gunnur Deniz¹  Sema Bilgic Gazioglu¹  Esin Aktas Cetin¹  Sinan Guloksuz²  Jim van Os³  E Timucin Oral⁴  Turan Cetin⁵ 

[1] Department of Immunology, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey;Department of Psychiatry and Psychology, Maastricht University Medical Centre, EURON, Maastricht, The Netherlands;Department of Psychiatry and Psychology, Maastricht University Medical Centre, EURON, Maastricht, The Netherlands;King’s College London, King’s Health Partners, Department of Psychosis Studies, Institute of Psychiatry, London, United Kingdom;Department of Psychology, Faculty of Arts and Sciences, Istanbul Commerce University, Istanbul, Turkey;Research, Treatment and Training Center for Alcohol and Substance Dependence (AMATEM), Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey;

关键词: Bipolar disorder;    Cytokine;    Interleukin;    Inflammation;    Tumor necrosis factor;    Euthymic;    Subsyndromal;    Staging;    Biomarker;   

DOI  :  10.1186/1471-244X-12-158

 received in 2012-05-17, accepted in 2012-09-21,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundCurrent evidence suggests that high concentrations of pro-inflammatory markers are associated with bipolar disorder characterized by severe impairment during inter-episodic periods, reduced treatment response and persistent subsyndromal symptoms. We tested whether persistent subsyndromal symptoms in euthymic bipolar patients were associated with markers of an ongoing chronic pro-inflammatory process.MethodsForty-five euthymic bipolar patients (22 with subsyndromal symptoms (BD+) and 23 without subsyndromal symptoms (BD-) and 23 well controls (WC) were recruited for assessment of soluble tumor necrosis factor receptor-1 (sTNF-R1), soluble interleukin-6 receptor (sIL-6R) and soluble interleukin-2 receptor (sIL-2R) concentrations. Soluble cytokine receptor concentrations were assessed using enzyme-linked immunosorbent assay.ResultsIn comparison to WC, sTNF-R1 concentration was higher in both BD- and BD+ (age and sex adjusted standardized β, respectively: β = 0.34, p = 0.012 and β = 0.41, p = 0.003). Similarly, compared to WC, sIL-6R concentration was higher in both BD- and BD+ (age and sex adjusted standardized β, respectively: β = 0.44, p = 0.001 and β = 0.37, p = 0.008). There was no difference between BD- and BD+ in the concentration of either sTNF-R1 or sIL-6R; plasma concentration of sIL-2R was not analyzed as 75% percent of the samples were non-detectable.ConclusionsAlthough bipolar patients present with a pro-inflammatory shift compared to well controls, subsyndromal symptoms are not associated with additive increasing effects. Longitudinal studies with larger samples are required to clarify the relationship between illness course and inflammatory markers in bipolar disorder.

【 授权许可】

Unknown   
© Cetin et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.