Low birth weight in offspring of women with depressive and anxiety symptoms during pregnancy: results from a population based study in Bangladesh

BMC Public Health

Research Article

Zarina Nahar Kabir¹  Maigun Edhborg¹  Yvonne Forsell²  Hashima E Nasreen³ 

[1] Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE-141 83, Huddinge, Stockholm, Sweden;Department of Public Health, Karolinska Institutet, SE-17176, Stockholm, Sweden;Research and Evaluation Division, BRAC, 75 Mohakhali, 1212, Dhaka, Bangladesh;School of Public Health, BRAC, 66 Mohakhali, 1212, Dhaka, Bangladesh;Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE-141 83, Huddinge, Stockholm, Sweden;

关键词: Depressive Symptom;    Anxiety Symptom;    State Trait Anxiety Inventory;    Maternal Depressive Symptom;    South Asian Country;   

DOI  :  10.1186/1471-2458-10-515

 received in 2010-03-31, accepted in 2010-08-26,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThere is a high prevalence of antepartum depression and low birth weight (LBW) in Bangladesh. In high- and low-income countries, prior evidence linking maternal depressive and anxiety symptoms with infant LBW is conflicting. There is no research on the association between maternal mental disorders and LBW in Bangladesh. This study aims to investigate the independent effect of maternal antepartum depressive and anxiety symptoms on infant LBW among women in a rural district of Bangladesh.MethodsA population-based sample of 720 pregnant women from two rural subdistricts was assessed for symptoms of antepartum depression, using the Edinburgh Postpartum Depression Scale (EPDS), and antepartum anxiety, using the State Trait Anxiety Inventory (STAI), and followed for 6-8 months postpartum. Infant birth weight of 583 (81%) singleton live babies born at term (≥37 weeks of pregnancy) was measured within 48 hours of delivery. Baseline data provided socioeconomic, anthropometric, reproductive, obstetric, and social support information. Trained female interviewers carried out structured interviews. Chi-square, Fisher's exact, and independent-sample t tests were done as descriptive statistics, and a multiple logistic regression model was used to identify predictors of LBW.ResultsAfter adjusting for potential confounders, depressive (OR = 2.24; 95% CI 1.37-3.68) and anxiety (OR = 2.08; 95% CI 1.30-3.25) symptoms were significantly associated with LBW (≤2.5 kg). Poverty, maternal malnutrition, and support during pregnancy were also associated with LBW.ConclusionsThis study provides evidence that maternal depressive and anxiety symptoms during pregnancy predict the LBW of newborns and replicates results found in other South Asian countries. Policies aimed at the detection and effective management of depressive and anxiety symptoms during pregnancy may reduce the burden on mothers and also act as an important measure in the prevention of LBW among offspring in Bangladesh.

【 授权许可】

CC BY   
© Nasreen et al; licensee BioMed Central Ltd. 2010