MYCbase: a database of functional sites and biochemical properties of Myc in both normal and cancer cells

BMC Bioinformatics

Database

Anubrata Bhattacharya¹  Debangana Chakravorty²  Sudipto Saha²  Tanmoy Jana²  Sukhen Das Mandal³  Anuradha Seth⁴ 

[1] Biochemistry Department, University of Calcutta, Kolkata, India;Bioinformatics Centre, Bose Institute, P 1/12, C.I.T. Road, Scheme-VII (M), 700054, Kolkata, India;Bioinformatics Centre, Bose Institute, P 1/12, C.I.T. Road, Scheme-VII (M), 700054, Kolkata, India;Current Address: Department of Biological sciences, Indian Institute of Science Education and Research, Kolkata, India;St.Xavier’s College, Kolkata, India;

关键词: Myc;    Cancer;    Mutations;    Protein-protein interactions;    Metabolism;   

DOI  :  10.1186/s12859-017-1652-6

 received in 2016-11-05, accepted in 2017-04-26,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMyc is an essential gene having multiple functions such as in cell growth, differentiation, apoptosis, genomic stability, angiogenesis, and disease biology. A large number of researchers dedicated to Myc biology are generating a substantial amount of data in normal and cancer cells/tissues including Burkitt’s lymphoma and ovarian cancer.ResultsMYCbase (http://bicresources.jcbose.ac.in/ssaha4/mycbase) is a collection of experimentally supported functional sites in Myc that can influence the biological cellular processes. The functional sites were compiled according to their role which includes mutation, methylation pattern, post-translational modifications, protein-protein interactions (PPIs), and DNA interactions. In addition, biochemical properties of Myc are also compiled, which includes metabolism/pathway, protein abundance, and modulators of protein-protein interactions. The OMICS data related to Myc- like gene expression, proteomics expression using mass-spectrometry and miRNAs targeting Myc were also compiled in MYCbase. The mutation and pathway data from the MYCbase were analyzed to look at the patterns and distributions across different diseases. There were few proteins/genes found common in Myc-protein interactions and Myc-DNA binding, and these can play a significant role in transcriptional feedback loops.ConclusionIn this report, we present a comprehensive integration of relevant information regarding Myc in the form of MYCbase. The data compiled in MYCbase provides a reliable data resource for functional sites at the residue level and biochemical properties of Myc in various cancers.

【 授权许可】

CC BY   
© The Author(s). 2017