Association between human cartilage glycoprotein 39 (YKL-40) and arterial stiffness in essential hypertension

BMC Cardiovascular Disorders

Research Article

Pei-Li Bu¹  Xiu-ling Wang¹  De-e Wei²  Yan Zhang³  Yi-biao Wang³  Lin-lin Guo³  Wei-hong Ma³  Yi-meng Du³ 

[1] Department of Cardiology, Qilu Hospital, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, 250012, Jinan, China;Department of Cardiology, The Central Hostpital of Jinan City of Shandong University, 250013, Jinan, China;Department of Cardiology, The Second Hospital of Shandong University, 250033, Jinan, China;

关键词: Essential Hypertension;    Arterial Stiffness;    Pulse Wave Velocity;    Peak Systolic Velocity;    Target Organ Damage;   

DOI  :  10.1186/1471-2261-12-35

 received in 2011-09-25, accepted in 2012-05-10,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundYKL-40, a proposed marker of inflammation and endothelial dysfunction, is associated with atherosclerosis and an increased cardiovascular mortality in the general population. However, the relationship between YKL-40 and arterial stiffness in hypertensive patients has not been adequately assessed.MethodsThe relationship between serum levels of YKL-40 and arterial stiffness was evaluated in 93 essential hypertensive subjects and 80 normal subjects. Essential hypertensive subjects were divided into two groups based upon urinary albumin-to-creatinine ratio (ACR): nonmicroalbuminuric group, (ACR <30 mg/g, n = 50) and microalbuminuric group (ACR ≥30 mg/g, n = 43). Large artery wall stiffness was assessed by measuring femoral arterial stiffness and carotid-femoral pulse wave velocity (cf-PWV). Serum levels of YKL-40 were determined by enzyme-linked immunosorbent assay (ELISA).ResultsThe study demonstrated that YKL-40,cf-PWV and femoral arterial stiffness were increased significantly (P<0.05) in the hypertensive group compared with normal controls. These measurements were also increased significantly ( P<0.05) in the microalbuminuric group compared with the nonmicroalbuminuric group. YKL-40 was positively correlated with cf-PWV( r = 0.44, P = 0.000) and femoral arterial stiffness ( r = 0.42, P =0.001). Multiple linear stepwise regression analysis showed that YKL-40 was the impact factor of arterial stiffness ( P<0.05).ConclusionYKL-40 levels are elevated in essential hypertension subjects with an independent association between increasing YKL-40 levels and increasing arterial stiffness. The study suggests it played a positive role of YKL-40 in the progressing vascular complications in patients with essential hypertension.

【 授权许可】

Unknown   
© Ma et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.