Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study

BMC Cancer

Research Article

Celestia S Higano¹  Paul R Borghesani²  Monique M Cherrier³  Amy L Shelton⁴ 

[1] Department of Medicine, University of Washington School of Medicine, 98195, Seattle, WA, USA;Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 98195, Seattle, WA, USA;Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 98195, Seattle, WA, USA;MIRECC VAPSHCS, 1660 S. Columbian Way, 98108, Seattle, WA, USA;Department of Psychological and Brain Sciences, Johns Hopkins University, Ames Hall/3400 North Charles Street, 21218, Baltimore, MD, USA;

关键词: Androgen Deprivation Therapy;    Mental Rotation;    Blood Oxygen Level Dependent;    Spatial Reasoning;    Blood Oxygen Level Dependent Signal;   

DOI  :  10.1186/1471-2407-10-1

 received in 2009-07-15, accepted in 2010-01-04,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundA common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects.MethodsIn this study, hormone naïve patients without evidence of metastases with a rising PSA were treated with nine months of ADT. Functional magnetic resonance imaging (fMRI) of the brain during three visuospatial tasks was performed at baseline prior to treatment and after nine months of ADT in five subjects. Seven healthy control patients, underwent neuroimaging at the same time intervals.ResultsADT patients showed reduced, task-related BOLD-fMRI activation during treatment that was not observed in control subjects. Reduction in activation in right parietal-occipital regions from baseline was observed during recall of the spatial location of objects and mental rotation.ConclusionsFindings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.

【 授权许可】

CC BY   
© Cherrier et al; licensee BioMed Central Ltd. 2010