A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats

BMC Complementary and Alternative Medicine

Research Article

Fazal Subhan¹  Nisar Ahmad¹  Muhammad Shahid²  Ihsan Ullah³ 

[1] Department of Pharmacy, University of Peshawar, 25120, Peshawar, Khyber Pakhtunkhwa, Pakistan;Department of Pharmacy, University of Peshawar, 25120, Peshawar, Khyber Pakhtunkhwa, Pakistan;Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan;Department of Pharmacy, University of Swabi, Swabi, Pakistan;

关键词: Bacopa monnieri;    Bacoside-A;    Rat model of neuropathy;    Nociception;    Pain paradigms;   

DOI  :  10.1186/s12906-017-1807-z

 received in 2016-08-25, accepted in 2017-05-26,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe current therapy of neuropathic pain is inadequate and is limited by the extent of pain relief and the occurrence of dose dependant side effects. Insufficient control of pain with conventional medications prompts the use of complementary and alternative medicine therapies by patients with neuropathic pain. This study therefore investigated a standardized methanolic extract of Bacopa monnieri, a widely reputed nootropic plant, for prospective antinociceptive effect in the chronic constriction injury (CCI) model of neuropathic pain.MethodsPlacement of four loose ligatures around the sciatic nerve produced partial denervation of the hindpaw in rats. Bacopa monnieri (40 and 80 mg/kg, p.o) and the positive control, gabapentin (75 mg/kg, i.p), were administered daily after CCI or sham surgery and the behavioral paradigms of static- and dynamic-allodynia (paw withdrawal threshold to von Frey filament stimulation [PWT] and paw withdrawal latency to light-brushing [PWL]), cold-allodynia (paw withdrawal duration [PWD] to acetone), heat- (PWL to heat-stimulus) and punctate-hyperalgesia (PWD to pin-prick) were assessed on days 3, 7, 14 and 21.ResultsCCI consistently generated static- (days 3–21), dynamic- (days 14–21) and cold-allodynia (days 3–21) plus heat- and mechano-hyperalgesia (days 3–21). The tested doses of Bacopa monnieri significantly attenuated the CCI-induced allodynia and hyperalgesia, exemplified by increased PWT (days 7–21), PWL to light brushing (days 14–21) and heat (days 7–21) as well as decreased PWD to pin prick and cold stimuli (days 3–21). The extract also counterbalanced the CCI-induced aberrations in the nociceptive behaviors by increasing the pain threshold to that of pre-surgery baseline. Gabapentin also afforded analogous beneficial behavioral profile but of higher magnitude.ConclusionsOur findings suggest that Bacopa monnieri can be used as adjuvant therapy for neuropathic pain conditions afflicted with allodynia and hyperalgesia.

【 授权许可】

CC BY   
© The Author(s). 2017