Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height – a 3.0 T-MRI study

BMC Musculoskeletal Disorders

Research Article

Flavia M. Cicuttini¹  Donna M. Urquhart¹  Yuanyuan Wang¹  Anita E. Wluka¹  Andrew J. Teichtahl²  Richard O’Sullivan³  Graeme Jones⁴ 

[1] Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004, Melbourne, VIC, Australia;Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004, Melbourne, VIC, Australia;Baker IDI Heart and Diabetes Institute, Commercial Road, 3004, Melbourne, VIC, Australia;Healthcare Imaging Services, Epworth Hospital, Richmond, 3121, Melbourne, VIC, Australia;Department of Medicine, Central Clinical School, Monash University, 3004, Melbourne, VIC, Australia;Menzies Research Institute, Private bag 23, 7000, Hobart, TAS, Australia;

关键词: Lumbar spine;    Intervertebral disc;    Modic;    Fat mass;    Fat free mass;    Android;    Gynoid;    Height;    Body composition;    MRI;    Adiposity;   

DOI  :  10.1186/s12891-016-0934-x

 received in 2015-12-04, accepted in 2016-02-06,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundVertebral endplate (Modic) abnormalities are important structural lesions in the spine, but their association with body composition and fat distribution have not been examined. Moreover, no study has examined whether Modic change are related to other structural features of low back pain, such as reduced intervertebral disc height.MethodsSeventy-two community-based individuals not selected for low back pain had lumbar vertebral Modic change and intervertebral disc height assessed from MRI. Dual energy x-ray absorptiometry measured body composition and fat distribution.ResultsThe predominance of Modic change was type 2. Modic change was associated with an increased fat mass index (OR 1.20, 95 % CI 1.01 to 1.43), and tended to be associated with a reduced fat-free mass index (OR 0.62, 95 % CI 0.37 to 1.03, p = 0.07). While an increased percentage of gynoid fat was associated with a reduced risk (OR 0.62, 95 % CI 0.43 to 0.89), an increased percentage of android fat was associated with an increased risk of Modic change (OR 2.11, 95 % CI 1.18 to 3.76). Modic change was also associated with reduced intervertebral disc height at L2/3, L4/5 and L5/S1 (OR range 1.4 to 1.8; all p ≤ 0.03).ConclusionModic type 2 change is associated with reduced intervertebral disc height and an increased fat mass index. Whereas gynoid fat distribution protected against Modic type 2 change, an android pattern increased the risk of this lesion. Modic type 2 change, which histologically represent fat replacement, might have a metabolic component to its aetiology.

【 授权许可】

CC BY   
© Teichtahl et al. 2016