Hemosiderin-laden macrophages are an independent factor correlated with pulmonary vascular resistance in idiopathic pulmonary fibrosis: a case control study

BMC Pulmonary Medicine

Research Article

Masahiko Ando¹  Junya Fukuoka²  Takeshi Johkoh³  Yasuhiro Kondoh⁴  Tomoki Kimura⁴  Jun Fukihara⁴  Hiroyuki Taniguchi⁴  Taiki Furukawa⁴  Kensuke Kataoka⁴  Yoshinori Hasegawa⁵  Koji Sakamoto⁵ 

[1] Center of Advanced Medicine and Clinical Research, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, 466-0065, Nagoya-shi, Aichi, Japan;Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki-shi, Nagasaki, Japan;Department of Radiology, Kinki Central Hospital of Mutual Aid Association of Public School Teachers, 3-1 Kurumazuka, 664-8533, Itami-shi, Hyogo, Japan;Department of Respiratory Medicine and Allergy, Tosei General Hospital, 160 Nishioiwake-cho, 489-8642, Seto-shi, Aichi, Japan;Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-0065, Nagoya-shi, Aichi, Japan;

关键词: Hemosiderin-laden macrophages;    Idiopathic pulmonary fibrosis;    Pulmonary vascular resistance;    Mean pulmonary arterial pressure;    Bronchoalveolar-lavage;    Right heart catheterization;   

DOI  :  10.1186/s12890-017-0376-8

 received in 2016-08-21, accepted in 2017-01-28,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundIncreases in hemosiderin-laden macrophages (HLM) are reported to be observed in idiopathic pulmonary fibrosis (IPF). According to a recent study, significant correlation between hemosiderin deposition in the lung tissue of IPF and pulmonary hypertension evaluated by echocardiography has been suspected. In this study, we aimed to evaluate whether HLM in bronchoalveolar lavage fluid (BALF) is a factor correlated with pulmonary hemodynamic parameters evaluated by right heart catheterization in patients with IPF.MethodsInitial data from 103 consecutive patients with IPF who underwent surgical lung biopsy between November 2007 and March 2014 were retrospectively analyzed. The “HLM score” of BALF was established by dividing the number of Perls’ Prussian blue stain positive macrophages by the total number of macrophages counted.ResultsBALF showed an elevated HLM score (38.2%). Right heart catheterization revealed mean pulmonary arterial pressure (mPAP) of 16.3 mmHg and pulmonary vascular resistance (PVR) of 1.55 Wood units. HLM score was positively correlated with mPAP (ρ = 0.204; p = 0.038) and PVR (ρ = 0.349, p < 0.001). In multivariate analysis, 6-min walk distance (standardized partial regression coefficient [β], −0.391; p < 0.001), minimum oxygen saturation during 6-min walk distance (β, −0.294; p = 0.001) and HLM score (β, 0.265; p = 0.002) were independently correlated with PVR.ConclusionsHLM score in BALF is an independent factor correlated with PVR in patients with IPF.

【 授权许可】

CC BY   
© The Author(s). 2017