An impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional study

BMC Psychiatry

Research Article

Rui Manuel Nunes Corredeira¹  Attilio Carraro²  Amber De Herdt³  Davy Vancampfort⁴  Dirk De Wachter⁴  Marc De Hert⁴  Michel Probst⁵ 

[1] CIAFEL - Centre for Research on Physical Activity, Health and Leisure, University of Porto, Porto, Portugal;Department of Philosophy, Sociology, Education and Applied Psychology (FISPPA), University of Padua, Padova, Italy;Faculty of Kinesiology and Rehabilitation Sciences, Catholic University Leuven, Leuven, Belgium;University Psychiatric Centre Catholic University Leuven, Campus Kortenberg, Kortenberg, Belgium;University Psychiatric Centre Catholic University Leuven, Campus Kortenberg, Kortenberg, Belgium;Faculty of Kinesiology and Rehabilitation Sciences, Catholic University Leuven, Leuven, Belgium;

关键词: Muscle weakness;    Fitness;    Physical activity;    Metabolic syndrome;    Walking;    Schizophrenia;   

DOI  :  10.1186/1471-244X-13-5

 received in 2012-08-17, accepted in 2013-01-02,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundPatients with schizophrenia report muscle weakness. The relation of this muscle weakness with performing daily life activities such as walking is however not yet studied. The aim of this study was to quantify walking capacity and health related muscular fitness in patients with schizophrenia compared with age-, gender and body mass index (BMI)-matched healthy controls. Secondly, we identified variables that could explain the variability in walking capacity and in health related muscular fitness in patients with schizophrenia.MethodsA total of 100 patients with schizophrenia and 40 healthy volunteers were initially screened. Eighty patients with schizophrenia (36.8±10.0 years) and the 40 age-, gender- and body mass index (BMI)-matched healthy volunteers (37.1±10.3 years) were finally included. All participants performed a standing broad jump test (SBJ) and a six-minute walk test (6MWT) and filled out the International Physical Activity Questionnaire. Patients additionally had a fasting metabolic laboratory screening and were assessed for psychiatric symptoms.ResultsPatients with schizophrenia did have lower 6MWT (17.9%, p<0.001) [effect size (ES)=−1.01] and SBJ (14.1%, p<0.001) (ES=−0.57) scores. Patients were also less physically active (1291.0±1201.8 metabolic equivalent-minutes/week versus 2463.1±1365.3, p<0.001) (ES=−0.91) than controls. Schizophrenia patients with metabolic syndrome (MetS) (35%) had a 23.9% lower (p<0.001) SBJ-score and 22.4% (p<0.001) lower 6MWT-score than those without MetS. In multiple regression analysis, 71.8% of the variance in 6MWT was explained by muscular fitness, BMI, presence of MetS and physical activity participation, while 53.9% of the variance in SBJ-score was explained by age, illness duration, BMI and physical activity participation.ConclusionsThe walking capacity and health-related muscular fitness are impaired in patients with schizophrenia and both should be a major focus in daily clinical practice and future research.

【 授权许可】

CC BY   
© Vancampfort et al.; licensee BioMed Central Ltd. 2013