Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study

BMC Cancer

Research Article

Gary R Zirpoli¹  Susan E McCann¹  Christine B Ambrosone¹  Li Tang¹  Vijayvel Jayaprakash¹  Kirsten B Moysich¹  Yuesheng Zhang¹  Mary E Reid²  Chukwumere E Nwogu³ 

[1] Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, 14263, Buffalo, NY, USA;Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, 14263, Buffalo, NY, USA;Department of Thoracic Surgery, Roswell Park Cancer Institute, Elm and Carlton Streets, 14263, Buffalo, NY, USA;

关键词: Lung Cancer;    Smoking Status;    Small Cell Carcinoma;    Vegetable Intake;    Lung Cancer Risk;   

DOI  :  10.1186/1471-2407-10-162

 received in 2009-10-28, accepted in 2010-04-27,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundInverse associations between cruciferous vegetable intake and lung cancer risk have been consistently reported. However, associations within smoking status subgroups have not been consistently addressed.MethodsWe conducted a hospital-based case-control study with lung cancer cases and controls matched on smoking status, and further adjusted for smoking status, duration, and intensity in the multivariate models. A total of 948 cases and 1743 controls were included in the analysis.ResultsInverse linear trends were observed between intake of fruits, total vegetables, and cruciferous vegetables and risk of lung cancer (ORs ranged from 0.53-0.70, with P for trend < 0.05). Interestingly, significant associations were observed for intake of fruits and total vegetables with lung cancer among never smokers. Conversely, significant inverse associations with cruciferous vegetable intake were observed primarily among smokers, in particular former smokers, although significant interactions were not detected between smoking and intake of any food group. Of four lung cancer histological subtypes, significant inverse associations were observed primarily among patients with squamous or small cell carcinoma - the two subtypes more strongly associated with heavy smoking.ConclusionsOur findings are consistent with the smoking-related carcinogen-modulating effect of isothiocyanates, a group of phytochemicals uniquely present in cruciferous vegetables. Our data support consumption of a diet rich in cruciferous vegetables may reduce the risk of lung cancer among smokers.

【 授权许可】

CC BY   
© Tang et al; licensee BioMed Central Ltd. 2010