Treatment of limited stage follicular lymphoma with Rituximab immunotherapy and involved field radiotherapy in a prospective multicenter Phase II trial-MIR trial

BMC Cancer

Study Protocol

Michael Unterhalt¹  Mathias Witzens-Harig²  Klaus Herfarth³  Manfred Hensel⁴ 

[1] Department Internal Medicine III, University of Munich (LMU), Marchioninistr. 15, 81377, Munich, Germany;Department of Internal Medicine V, University of Heidelberg, INF 410 69120, Heidelberg, Germany;Department of Radiation Oncology, University of Heidelberg, INF 400, 69120, Heidelberg, Germany;Onkologische Schwerpunkt Praxis, Q5 14-22, 68161, Mannheim, Germany;

关键词: Follicular Lymphoma;    Mantle Cell Lymphoma;    Overall Response Rate;    Complete Remission Rate;    Relapse Free Survival;   

DOI  :  10.1186/1471-2407-11-87

 received in 2010-05-15, accepted in 2011-02-26,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe optimal treatment of early stage follicular Lymphoma is a matter of debate. Radiation therapy has frequently been applied with a curative approach beside watchful waiting. Involved field, extended field and total nodal radiation techniques are used in various protocols, but the optimal radiation field still has to be defined. Follicular lymphoma is characterized by stable expression of the CD20 antigen on the tumour cells surface. The anti CD20 antibody Rituximab (Mabthera®) has shown to be effective in systemic therapy of FL in primary treatment, relapse and maintenance therapy.Methods/designThe MIR (Mabthera® and Involved field Radiation) study is a prospective multicenter trial combining systemic treatment with the anti CD20 antibody Rituximab (Mabthera®) in combination with involved field radiotherapy (30 - 40 Gy). This trial aims at testing the combination's efficacy and safety with an accrual of 85 patients.Primary endpoint of the study is progression free survival. Secondary endpoints are response rate to Rituximab, complete remission rate at week 18, relapse rate, relapse pattern, relapse free survival, overall survival, toxicity and quality of life.DiscussionThe trial evaluates the efficacy of Rituximab to prevent out-filed recurrences in early stage nodal follicular lymphoma and the safety of the combination of Rituximab and involved field radiotherapy. It also might show additional risk factors for a later recurrence (e.g. remission state after Rituximab only).Trial RegistrationClinicalTrials (NCT): NCT00509184

【 授权许可】

Unknown   
© Witzens-Harig et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.