Impact of Moringa oleifera lam. Leaf powder supplementation versus nutritional counseling on the body mass index and immune response of HIV patients on antiretroviral therapy: a single-blind randomized control trial

BMC Complementary and Alternative Medicine

Research Article

Henri Mukumbi¹  Philippe Donnen²  Michèle Dramaix-Wilmet³  Pierre Duez⁴  Koy Tshingani⁵ 

[1] Actions Communautaires SIDA/Avenir meilleur pour les Orphelins en République Démocratique du Congo (ACS/AMOCONGO), Kinshasa, Democratic Republic of the Congo;Centre de Recherche en Politique et Système de santé – Santé Internationale, Brussels, Belgium;Centre de Recherche en Épidémiologie, Biostatistiques and Recherche clinique, École de Santé publique/Université libre de Bruxelles (ULB), Brussels, Belgium;Department of Therapeutic Chemistry and Pharmacognosy, University of Mons, Mons, Belgium;Higher Institute of the Medical Techniques of Kinshasa (ISTM), Kinshasa, Democratic Republic of the Congo;Centre de Recherche en Épidémiologie, Biostatistiques and Recherche clinique, École de Santé publique/Université libre de Bruxelles (ULB), Route de Lennik n 808, CP 1070, Anderlecht, Brussels, Belgium;

关键词: Moringa oleifera;    Supplementation;    HIV;    Antiretroviral therapy;    DR Congo;    Body mass index;    CD4 count;   

DOI  :  10.1186/s12906-017-1920-z

 received in 2017-01-15, accepted in 2017-08-11,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTo achieve effective antiretroviral therapy (ART) outcomes, adherence to an antiretroviral regimen and a good immunometabolic response are essential. Food insecurity can act as a real barrier to adherence to both of these factors. Many people living with human immunodeficiency virus (PLHIV) treated with ART in the Democratic Republic of the Congo (DRC) are faced with nutritional challenges. A significant proportion are affected by under nutrition, which frequently leads to therapeutic failure. Some HIV care facilities recommend supplementation with Moringa oleifera (M.O.) Lam. leaf powder to combat marginal and major nutritional deficiencies. This study aims to assess the impact of M.O. Lam. leaf powder supplementation compared to nutritional counseling on the nutritional and immune status of PLHIV treated with ART.MethodsA single-blind randomized control trial was carried out from May to September 2013 at an outpatient clinic for HIV-infected patients in Kinshasa (DRC). Sixty adult patients who were at stable HIV/AIDS clinical staging 2, 3 or 4 according to the World Health Organization (WHO), and were undergoing ART were recruited.After random allocation, 30 patients in the Moringa intervention group (MG) received the M.O. Lam. leaf powder daily over 6 months, and 30 in the control group (CG) received nutritional counseling over the same period.Changes in the body mass index (BMI) were measured monthly and biological parameters were measured upon admission and at the end of the study for the patients in both groups.ResultsThe two study groups were similar in terms of long-term nutritional exposure, sociodemographic, socioeconomic, clinical, and biological features. At 6 months follow-up, patients in the MG exhibited a significantly greater increase in BMI and albumin levels than those in the CG. The interaction between the sociodemographic, clinical, and biological characteristics of patients in the two groups was not significant, with the exception of professional activity.ConclusionsUnder medical supervision, M.O. Lam. leaf powder supplementation may represent a readily available and effective local solution to improve the nutritional intake and nutritional status of PLHIV undergoing ART.Trial registrationThe study was retrospectively registered in the Pan African Clinical Trial Registry on 15 May 2015, no. PACTR201505001076143.

【 授权许可】

CC BY   
© The Author(s). 2017