Alveolar Rhabdomyosarcoma of the foot metastasizing to the Iris: report of a rare case

BMC Cancer

Case Report

Tina Foord¹  Ido Didi Fabian²  Mandeep S. Sagoo³  G. Darius Hildebrand⁴  Shaun Wilson⁵ 

[1] Churchill Hospital, Oxford University Hospitals, Oxford, UK;Ocular Oncology Service, Moorfields Eye Hospital, 162 City Road, EC1V 2PD, London, UK;St. Bartholomew’s Hospital, London, UK;Ocular Oncology Service, Moorfields Eye Hospital, 162 City Road, EC1V 2PD, London, UK;St. Bartholomew’s Hospital, London, UK;UCL Institute of Ophthalmology, London, UK;Oxford Eye Hospital, The John Radcliffe Hospital, Oxford University Hospitals, Oxford, UK;Paediatric Haematology/Oncology Department, John Radcliffe Hospital, Oxford University Hospitals, Oxford, UK;

关键词: Rhabdomyosarcoma;    Iris;    Metastasis;    Case report;   

DOI  :  10.1186/s12885-016-2496-6

 received in 2016-02-18, accepted in 2016-06-28,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundIntraocular iris rhabdomyosarcoma is extremely rare, and in the 3 cases reported to date occurred as the primary site of tumour growth. We report a case of rhabdomyosarcoma of the foot metastasizing to the iris.Case presentationAn 18-year-old white female was referred to the London Ocular Oncology Service for management of a metastatic rhabdomyosarcomatous deposit in the iris, a metastasis from alveolar rhabdomyosarcoma of the foot. She was diagnosed nearly 2 years earlier with the primary sarcoma with extensive systemic spread and treated by resection of the foot lesion and chemotherapy, and achieved a partial remission. The left iris deposit was noted while she was receiving systemic chemotherapy, heralding a relapse. However, anterior uveitis and raised intraocular pressure developed and she was referred to our service for further management. A left iris secondary rhabdomyosarcoma deposit was noticed and in addition a lacrimal gland mass, as indicated by ultrasound B scan of the eye and orbit. The patient was treated with external beam radiotherapy to the globe and orbit, but died 2 months after treatment completion.ConclusionRhabdomyosarcoma of the iris is very rare and was previously documented only as a primary malignancy in this location. We report that secondary spread to the iris can also occur, in this case as the first sign of widely disseminated systemic relapse.

【 授权许可】

CC BY   
© The Author(s). 2016