Visual detection of cortical breaks in hand joints: reliability and validity of high-resolution peripheral quantitative CT compared to microCT

BMC Musculoskeletal Disorders

Research Article

B. van Rietbergen¹  A. van Tubergen²  P. Geusens³  J. de Jong⁴  A. Scharmga⁵  M. Peters⁵  J. van den Bergh⁶  R. Weijers⁷  D. Loeffen⁷ 

[1] Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands;Department of Medicine, division of Rheumatology, Maastricht University Medical Centre, P.O. Box 5800, NL-6202 AZ, Maastricht, The Netherlands;CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands;Department of Medicine, division of Rheumatology, Maastricht University Medical Centre, P.O. Box 5800, NL-6202 AZ, Maastricht, The Netherlands;CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands;Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium;Department of Medicine, division of Rheumatology, Maastricht University Medical Centre, P.O. Box 5800, NL-6202 AZ, Maastricht, The Netherlands;NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands;Department of Medicine, division of Rheumatology, Maastricht University Medical Centre, P.O. Box 5800, NL-6202 AZ, Maastricht, The Netherlands;NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands;CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands;Department of Medicine, division of Rheumatology, Maastricht University Medical Centre, P.O. Box 5800, NL-6202 AZ, Maastricht, The Netherlands;NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands;Department of Internal Medicine, Viecuri Medical Center, Venlo, The Netherlands;Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium;Department of Radiology, Maastricht University Medical Centre, Maastricht, The Netherlands;

关键词: Imaging;    Computed tomography;    Hand;    Bone;    Rheumatoid arthritis;   

DOI  :  10.1186/s12891-016-1148-y

 received in 2016-04-07, accepted in 2016-06-29,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundTo study the reliability and validity of high-resolution peripheral quantitative CT (HR-pQCT) with microCT (μCT) as gold standard in the visual detection of cortical breaks in metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints.MethodsTen cadaveric fingers (10 MCP and 9 PIP joints) were imaged by HR-pQCT and μCT and visually analyzed by two independent readers. Intra- and interreader reliability were evaluated for the presence (yes/no, kappa statistics) and the total number (intraclass correlation coefficient, ICC) of cortical breaks. Sensitivity, specificity, positive and negative predictive value (PPV respectively NPV) of HR-pQCT in detecting cortical breaks were calculated.ResultsWith HR-pQCT, mean 149 cortical breaks were identified and with μCT mean 129 (p < 0.05). Intrareader reliability for the presence of a cortical break per quadrant was 0.52 (95 % CI 0.48–0.56) and 0.71 (95 % CI 0.67–0.75) for HR-pQCT and μCT, respectively, and for the total number of cortical breaks 0.61 (95 % CI 0.49–0.70) and 0.75 (95 % CI 0.68–0.82). Interreader reliability for the presence of a cortical break per quadrant was 0.37 (95 % CI 0.33–0.41) and 0.45 (95 % CI 0.41–0.49) for HR-pQCT and μCT, respectively, and for the number of cortical breaks 0.55 (95 % CI 0.43–0.65) and 0.54 (95 % CI 0.35–0.67). Sensitivity, specificity, PPV and NPV of HR-pQCT were 81.6, 64.0, 81.6, and 64 % respectively.ConclusionCortical breaks were commonly visualized in MCP and PIP joints with HR-pQCT and μCT. Reliability of both HR-pQCT and μCT was fair to moderate. HR-pQCT was highly sensitive to detect cortical breaks with μCT as gold standard.

【 授权许可】

CC BY   
© The Author(s). 2016