Serum neutrophil gelatinase-associated lipocalin and resistin are associated with dengue infection in adults

BMC Infectious Diseases

Research Article

Yao-Hua Liu¹  Meng-Chi Yen¹  Ming-Ju Tsai²  Kuan-Ting Liu³  Po-Lin Kuo⁴  Ya-Ling Hsu⁵  Chun-Yu Lin⁶ 

[1] Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, 807, Kaohsiung, Taiwan;Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 807, Kaohsiung, Taiwan;Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, No.100, Shih-Chuan 1st Road, 807, Kaohsiung, Taiwan;Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, 807, Kaohsiung, Taiwan;School of Medicine, College of Medicine, Kaohsiung Medical University, 807, Kaohsiung, Taiwan;Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, No.100, Shih-Chuan 1st Road, 807, Kaohsiung, Taiwan;Institute of Medical Science and Technology, National Sun Yat-Sen University, 804, Kaohsiung, Taiwan;Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 807, Kaohsiung, Taiwan;School of Medicine, College of Medicine, Kaohsiung Medical University, 807, Kaohsiung, Taiwan;Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 807, Kaohsiung, Taiwan;

关键词: Dengue;    Neutrophil gelatinase-associated lipocalin (NGAL);    Resistin;    Serum;   

DOI  :  10.1186/s12879-016-1759-9

 received in 2016-01-21, accepted in 2016-08-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundDengue is a major health problem in tropical areas, including Taiwan. Dengue virus infection affects various types of cells and results in elevation of serum inflammatory molecules. Because these molecules may be associated with dengue virus infection, the aim of this study was to identify novel molecules in febrile patients with dengue infection. In addition, we determined whether these molecules were correlated with the count of leukocytes and platelets.MethodsFebrile adults (Age >18 years old) who presented to the emergency department and were confirmed dengue virus infection were enrolled in this study. Serum from dengue patients and healthy controls was collected and serum level of sepsis-associated inflammatory molecules was measured by Luminex assay.ResultsElevated level of macrophage migration inhibitory factor, soluble vascular cell adhesion molecule-1, sFasL, resistin and interferon-γ were detected in patients’ serum. Higher levels of neutrophil gelatinase-associated lipocalin (NGAL) and resistin were detected in dengue patients with normal leukocyte count and all dengue patients, respectively. Furthermore, the serum level of NGAL, but not resistin, was correlated with cell count in dengue patients.ConclusionOur results revealed that resistin and NGAL are novel dengue-associated molecules. These results may help elucidate the regulatory mechanisms of anti-dengue immune responses.

【 授权许可】

CC BY   
© The Author(s). 2016