Effects of a progressive aquatic resistance exercise program on the biochemical composition and morphology of cartilage in women with mild knee osteoarthritis: protocol for a randomised controlled trial

BMC Musculoskeletal Disorders

Study Protocol

Miika T Nieminen¹  Benjamin Waller²  Matti Munukka²  Ari Heinonen²  Timo Rantalainen²  Juhani Multanen²  Urho M Kujala²  Arja Häkkinen³  Sarianna Sipilä⁴  Tapani Pöyhönen⁵  Ilkka Kiviranta⁶  Joost Dekker⁷  Harri Selänne⁸  Hannu Kautiainen⁹ 

[1] Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland;Department of Radiology, University of Oulu, Oulu, Finland;Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland;Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland;Department of Physical Medicine and Rehabilitation, Central Finland Central Hospital, Jyväskylä, Finland;Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland;Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland;Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland;Rehabilitation and Pain Unit, Kymenlaakso Central Hospital, Kotka, Finland;Department of Orthopaedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Department of Orthopaedics and Traumatology, Jyväskylä Central Hospital, Jyväskylä, Finland;Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands;LIKES Research Centre, Jyväskylä, Finland;Unit of Family Practice, Central Finland Central Hospital, Jyväskylä, Finland;

关键词: Osteoarthritis;    Quantitative MRI;    T2 relaxation time;    dGEMRIC;    Bone;    Aquatic exercise;   

DOI  :  10.1186/1471-2474-14-82

 received in 2013-02-07, accepted in 2013-02-27,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundSymptoms associated with osteoarthritis of the knee result in decreased function, loss of working capacity and extensive social and medical costs. There is a need to investigate and develop effective interventions to minimise the impact of and even prevent the progression of osteoarthritis. Aquatic exercise has been shown to be effective at reducing the impact of osteoarthritis. The purpose of this article is to describe the rationale, design and intervention of a study investigating the effect of an aquatic resistance exercise intervention on cartilage in postmenopausal women with mild knee osteoarthritis.MethodsA minimum of 80 volunteers who meet the inclusion criteria will be recruited from the local population through newspaper advertisements. Following initial assessment volunteers will be randomised into two groups. The intervention group will participate in a progressive aquatic resistance exercise program of 1-hour duration 3 times a week for four months. The control group will be asked to maintain normal care during this period. Primary outcome measure for this study is the biochemical composition of knee cartilage measured using quantitative magnetic resonance imaging; T2 relaxation time and delayed gadolinium-enhanced magnetic resonance imaging techniques. In addition, knee cartilage morphology as regional cartilage thickness will be studied. Secondary outcomes include measures of body composition and bone traits using dual energy x-ray absorptiometry and peripheral quantitative computed tomography, pain, function using questionnaires and physical performance tests and quality of life. Measurements will be performed at baseline, after the 4-month intervention period and at one year follow up.DiscussionThis randomised controlled trial will investigate the effect a progressive aquatic resistance exercise program has on the biochemical composition of cartilage in post-menopausal women with mild knee osteoarthritis. This is the first study to investigate what impact aquatic exercise has on human articular cartilage. In addition it will investigate the effect aquatic exercise has on physical function, pain, bone and body composition and quality of life. The results of this study will help optimise the prescription of aquatic exercise to persons with mild knee osteoarthritis.Trial RegistrationISRCTN65346593

【 授权许可】

CC BY   
© Waller et al; licensee BioMed Central Ltd. 2013