Initiation and completion rates for latent tuberculosis infection treatment: a systematic review

BMC Infectious Diseases

Research Article

Andreas Sandgren¹  Marije Vonk Noordegraaf-Schouten²  Femke van Kessel²  Anouk Oordt-Speets²  Anke Stuurman²  Marieke J. van der Werf³ 

[1] Former Surveillance and Response Section, European Centre for Disease Prevention and Control (ECDC), 171 65, Stockholm, Sweden;Pallas, Health Research and Consultancy B.V., 3001, Rotterdam, The Netherlands;Tomtebodavägen 11a, 171 65, Solna, Sweden;

关键词: Tuberculosis;    Latent tuberculosis;    Treatment initiation;    Treatment completion;    Risk groups;   

DOI  :  10.1186/s12879-016-1550-y

 received in 2016-02-16, accepted in 2016-05-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundControl of latent tuberculosis infection (LTBI) is an important step towards tuberculosis elimination. Preventive treatment will prevent the development of disease in most cases diagnosed with LTBI. However, low initiation and completion rates affect the effectiveness of preventive treatment. The objective was to systematically review data on initiation rates and completion rates for LTBI treatment regimens in the general population and specific populations with LTBI.MethodsA systematic review of the literature (PubMed, Embase) published up to February 2014 was performed.ResultsForty-five studies on initiation rates and 83 studies on completion rates of LTBI treatment were found. These studies provided initiation rates (IR) and completion rates (CR) in people with LTBI among the general population (IR 26–99 %, CR 39–96 %), case contacts (IR 40–95 %, CR 48–82 %), healthcare workers (IR 47–98 %, CR 17–79 %), the homeless (IR 34–90 %, CR 23–71 %), people who inject drugs (IR 52–91 %, CR 38–89 %), HIV-infected individuals (IR 67–92 %, CR 55–95 %), inmates (IR 7–90 %, CR 4–100 %), immigrants (IR 23–97 %, CR 7–86 %), and patients with comorbidities (IR 82–93 %, CR 75–92 %). Generally, completion rates were higher for short than for long LTBI treatment regimens.ConclusionInitiation and completion rates for LTBI treatment regimens were frequently suboptimal and varied greatly within and across different populations.

【 授权许可】

CC BY   
© Sandgren et al. 2016