Prevalence of mood and anxiety disorder in self reported irritable bowel syndrome (IBS). An epidemiological population based study of women

BMC Gastroenterology

Research Article

Arnstein Mykletun¹  Margaret Henry²  Mark A Kotowicz²  Julie Pasco²  Geoffrey C Nicholson²  Felice Jacka²  Lana Williams²  Michael Berk³ 

[1] Norwegian Institute of Public Health, Division of Mental Heath, Oslo, Norway;University of Bergen, Faculty of Psychology, Section Mental Health Epidemiology, Norway;The University of Melbourne, Department of Clinical and Biomedical Sciences: Barwon Health, Geelong, Australia;The University of Melbourne, Department of Clinical and Biomedical Sciences: Barwon Health, Geelong, Australia;Orygen Research Centre, Parkville, Australia;Mental Health Research Institute, Parkville, Australia;

关键词: Major Depressive Disorder;    Irritable Bowel Syndrome;    Anxiety Disorder;    Mood Disorder;    Chronic Fatigue Syndrome;   

DOI  :  10.1186/1471-230X-10-88

 received in 2010-04-14, accepted in 2010-08-05,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundIrritable bowel syndrome (IBS) is commonly regarded as a functional disorder, and is hypothesized to be associated with anxiety and depression. This evidence mainly rests on population-based studies utilising self-report screening instruments for psychopathology. Other studies applying structured clinical interviews are generally based on small clinical samples, which are vulnerable to biases. The extant evidence base for an association between IBS and psychopathology is hence not conclusive. The aim of this study was therefore to re-examine the hypothesis using population-based data and psychiatric morbidity established with a structured clinical interview.MethodsData were derived from a population-based epidemiological study (n = 1077). Anxiety and mood disorders were established using the Structured Clinical Interview for DSM-IV-TR (SCID-I/NP) and the General Health Questionnaire (GHQ-12). Current and lifetime IBS was self-reported. Hypertension and diabetes were employed as comparison groups as they are expected to be unrelated to mental health.ResultsCurrent IBS (n = 69, 6.4%) was associated with an increased likelihood of current mood and/or anxiety disorders (OR = 2.62, 95%CI 1.49 - 4.60). Half the population reporting a lifetime IBS diagnosis also had a lifetime mood or anxiety disorder. Exploratory analyses demonstrated an increased prevalence of IBS across most common anxiety and mood disorders, the exception being bipolar disorder. The association with IBS and symptoms load (GHQ-12) followed a curved dose response pattern. In contrast, hypertension and diabetes were consistently unrelated to psychiatric morbidity.ConclusionsIBS is significantly associated with anxiety and mood disorders. This study provides indicative evidence for IBS as a disorder with a psychosomatic aspect.

【 授权许可】

CC BY   
© Mykletun et al; licensee BioMed Central Ltd. 2010