Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

BMC Gastroenterology

Research Article

Matthias Kloor¹  Roberto Barale²  Monika Morak³  Elke Holinski-Feder³  Jan Novotny⁴  Heike Görgens⁵  Hans K Schackert⁵  Federico Canzian⁶  Asta Försti⁷  Kari Hemminki⁷  Daniele Campa⁸  Alessio Naccarati⁹  Barbara Pardini⁹  Ludmila Vodickova⁹  Pavel Vodicka⁹  Peter Propping^1,10  Nils Rahner^1,10  Verena Steinke^1,10  Beate Betz^1,11  Christoph Engel^1,12  Reinhard Büttner^1,13  Judith Kötting^1,14 

[1] Department of Applied Tumour Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany;Department of Biology, University of Pisa, Pisa, Italy;Department of Internal Medicine, Campus Innenstadt, University Hospital of Ludwig-Maximilians-University, Munich, Germany;Department of Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic;Department of Surgical Research, Technische Universität Dresden, Dresden, Germany;Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany;Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany;Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden;Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany;Department of Biology, University of Pisa, Pisa, Italy;Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic;Institute of Human Genetics, University of Bonn, Bonn, Germany;Institute of Human Genetics, University of Düsseldorf, Düsseldorf, Germany;Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany;Institute of Pathology, University of Bonn, Bonn, Germany;Medical Department, Knappschaftskrankenhaus, Ruhr University, Bochum, Germany;

关键词: Ghrelin Level;    German Population;    Colorectal Cancer Risk;    SNPs Rs27647;    Growth Hormone Secretagogue Receptor;   

DOI  :  10.1186/1471-230X-10-112

 received in 2010-04-14, accepted in 2010-09-28,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundGhrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development.MethodsWe conducted a case-control study to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with colorectal cancer risk. Pairwise tagging was used to select the 11 polymorphisms included in the study. The selected polymorphisms were genotyped in 680 cases and 593 controls from the Czech Republic.ResultsWe found two SNPs associated with lower risk of colorectal cancer, namely SNPs rs27647 and rs35683. We replicated the two hits, in additional 569 cases and 726 controls from Germany.ConclusionA joint analysis of the two populations indicated that the T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004).

【 授权许可】

CC BY   
© Campa et al; licensee BioMed Central Ltd. 2010