Internet-based perioperative exercise program in patients with Barrett’s carcinoma scheduled for esophagectomy [iPEP - study] a prospective randomized-controlled trial

BMC Cancer

Study Protocol

Oana Brosteanu¹  Torben Glatz²  Jens Hoeppner²  Hauke Lang³  Peter P. Grimminger³  Suzan Tug⁴  Daniel Pfirrmann⁴  Perikles Simon⁴  Ines Gockel⁵  Matthias Mehdorn⁵  Martin Busse⁶  Florian Lordick⁷ 

[1] Clinical Trial Centre Leipzig, University Leipzig, Leipzig, Germany;Department of General and Visceral Surgery Medical Centre, University of Freiburg, Freiburg, Germany;Department of General, Visceral and Transplant Surgery, University Hospital of Mainz, Mainz, Germany;Department of Sports Medicine, Disease Prevention and Rehabilitation, Johannes Gutenberg-University of Mainz, Albert-Schweitzer-Str. 22, D-55128, Mainz, Germany;Department of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany;Institute for Sports Medicine and Prevention, University of Leipzig, Leipzig, Germany;University Cancer Centre Leipzig, University Medicine Leipzig, Leipzig, Germany;

关键词: Perioperative;    Internet-based;    Oesophageal cancer;    Exercise;   

DOI  :  10.1186/s12885-017-3400-8

 received in 2015-10-16, accepted in 2017-06-01,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPatients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonary complications. This is partly due to one-lung ventilation during thoracotomy. This often accounts for prolonged stay on intensive care units, delayed postoperative reconvalescence and reduced quality of life. Socioeconomic disadvantages can result from these problems. Physical preconditioning has become a crucial leverage to optimize fitness and lung function in patients scheduled for esophagectomy, in particular during the time period of neoadjuvant therapy.Methods/Study designWe designed a prospective multicenter randomized-controlled trial. The objective is to evaluate the impact of an internet-based exercise program on postoperative respiratory parameters and pneumonia rates in patients with Barrett’s carcinoma scheduled for esophagectomy. Patients are randomly assigned to either execute internet-based perioperative exercise program (iPEP), including daily endurance, resistance and ventilation training or treatment as usual (TAU). During neoadjuvant therapy and recovery, patients in the intervention group receive an individually designed intensive exercise program based on functional measurements at baseline. Personal feedback of the supervisor with customized training programs is provided in weekly intervals.DiscussionThis study will evaluate if an intensive individually adapted training program via online supervision during neoadjuvant therapy will improve cardiorespiratory fitness and reduce pulmonary complications following esophagectomy for Barrett’s cancer.Trial registrationNCT02478996, registered 26 May 2015.

【 授权许可】

CC BY   
© The Author(s). 2017