Comparison of ankle-brachial pressure index and pulse wave velocity as markers of cognitive function in a community-dwelling population

BMC Psychiatry

Research Article

Norio Yasui-Furukori¹  Sunao Kaneko¹  Ayako Kaneda¹  Norio Sugawara²  Yasushi Sato²  Takashi Umeda³  Kazuma Danjo³  Shigeyuki Nakaji³  Masashi Matsuzaka³  Ippei Takahashi³ 

[1] Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan;Department of Psychiatry, Hirosaki-Aiseikai Hospital, Hirosaki, Japan;Department of Social Medicine, Hirosaki University School of Medicine, Hirosaki, Japan;

关键词: Cognitive Impairment;    Cognitive Decline;    Arterial Stiffness;    Pulse Wave Velocity;    MMSE Score;   

DOI  :  10.1186/1471-244X-10-46

 received in 2010-01-17, accepted in 2010-06-10,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundVascular factors have been implicated in the development of cognitive decline and dementia. The purpose of this study is to determine the association of the Ankle Brachial pressure Index (ABI) and brachial-ankle Pulse Wave Velocity (ba-PWV) to cognitive impairment in a community-dwelling population.MethodsThe ABI and ba-PWV were measured using the volume-plethymographic apparatus in 388 subjects aged 60 years old and over. The Mini-Mental State Examination was also employed to measure global cognitive status. The effectiveness of the ABI and ba-PWV as putative markers of cognitive impairment were determined by using a multiple logistic regression analysis after adjusting for confounding factors.ResultsSubjects with poor cognition were significantly older and less well educated than those with normal cognition. According to the multiple logistic regression analysis, the lowest ABI tertile was found to be a significant independent risk factor (OR = 3.19, 95% CI = 1.30 to 7.82) of the cognitive impairment, whereas the highest brachial-ankle PWV tertile was not.ConclusionsA low ABI was an independent risk factor for cognitive impairment in community-dwelling older populations, whereas a high ba-PWV may not be. Further research will be required to analyze ABI and PWV with greater accuracy.

【 授权许可】

CC BY   
© Sugawara et al; licensee BioMed Central Ltd. 2010