Difference of clinical features in childhood Mycoplasma pneumoniae pneumonia

BMC Pediatrics

Research Article

Joon-Sung Lee¹  Kyung-Yil Lee¹  You-Sook Youn¹  Jin-Han Kang¹  Ja-Young Hwang¹  Jung-Woo Rhim¹  Ji-Chang Kim² 

[1] Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea;Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, South Korea;

关键词: Respiratory Syncytial Virus;    Severe Acute Respiratory Syndrome;    Lower Respiratory Tract Infection;    Roxithromycin;    Mycoplasma Pneumoniae;   

DOI  :  10.1186/1471-2431-10-48

 received in 2009-08-27, accepted in 2010-07-06,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundM. pneumoniae pneumonia (MP) has been reported in 10-40% of community-acquired pneumonia cases. We aimed to evaluate the difference of clinical features in children with MP, according to their age and chest radiographic patterns.MethodsThe diagnosis of MP was made by examinations at both admission and discharge and by two serologic tests: the indirect microparticle agglutinin assay (≥1:40) and the cold agglutinins titer (≥1:32). A total of 191 children with MP were grouped by age: ≤2 years of age (29 patients), 3-5 years of age (81 patients), and ≥6 years of age (81 patients). They were also grouped by pneumonia pattern: bronchopneumonia group (96 patients) and segmental/lobar pneumonia group (95 patients).ResultsEighty-six patients (45%) were seroconverters, and the others showed increased antibody titers during hospitalization. Among the three age groups, the oldest children showed the longest duration of fever, highest C-reactive protein (CRP) values, and the most severe pneumonia pattern. The patients with segmental/lobar pneumonia were older and had longer fever duration and lower white blood cell (WBC) and lymphocyte counts, compared with those with bronchopneumonia. The patient group with the most severe pulmonary lesions had the most prolonged fever, highest CRP, highest rate of seroconverters, and lowest lymphocyte counts. Thrombocytosis was observed in 8% of patients at admission, but in 33% of patients at discharge.ConclusionsIn MP, older children had more prolonged fever and more severe pulmonary lesions. The severity of pulmonary lesions was associated with the absence of diagnostic IgM antibodies at presentation and lymphocyte count. Short-term paired IgM serologic test may be mandatory for early and definitive diagnosis of MP.

【 授权许可】

Unknown   
© Youn et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.