Cardiovascular risk associated with the use of glitazones, metformin and sufonylureas: meta-analysis of published observational studies

BMC Cardiovascular Disorders

Research Article

Brian Calingaert¹  Nuria Riera-Guardia²  Susana Perez-Gutthann²  Cristina Varas-Lorenzo²  Andrea V Margulis²  Manel Pladevall³ 

[1] RTI Health Solutions, Research Triangle Park, NC, USA;RTI Health Solutions, Trav. Gracia 56 Atico 1 08006, Barcelona, Spain;RTI Health Solutions, Trav. Gracia 56 Atico 1 08006, Barcelona, Spain;The Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Michigan, USA;

关键词: Blood glucose–lowering drugs;    Type 2 diabetes mellitus;    Stroke;    AMI;    Meta-analysis;    Cardiovascular safety;    Pharmacoepidemiology;    Observational studies;   

DOI  :  10.1186/s12872-016-0187-5

 received in 2015-09-03, accepted in 2016-01-08,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe results of observational studies evaluating and comparing the cardiovascular safety of glitazones, metformin and sufonylureas are inconsistent.To conduct and evaluate heterogeneity in a meta-analysis of observational studies on the risk of acute myocardial infarction (AMI) or stroke in patients with type 2 diabetes using non-insulin blood glucose–lowering drugs (NIBGLD).MethodsWe systematically identified and reviewed studies evaluating NIBGLD in patients with type 2 diabetes indexed in Medline, Embase, or the Cochrane Library that met prespecified criteria. The quality of included studies was assessed with the RTI item bank. Results were combined using fixed- and random-effects models, and the Higgins I2 statistic was used to evaluate heterogeneity. Sensitivity analyses by study quality were conducted.ResultsThe summary relative risk (sRR) (95 % CI) of AMI for rosiglitazone versus pioglitazone was 1.13 (1.04–1.24) [I2 = 55 %]. In the sensitivity analysis, heterogeneity was reduced [I2 = 16 %]. The sRR (95 % CI) of stroke for rosiglitazone versus pioglitazone was 1.18 (1.02–1.36) [I2 = 42 %]. There was strong evidence of heterogeneity related to study quality in the comparisons of rosiglitazone versus metformin and rosiglitazone versus sulfonylureas (I2 ≥ 70 %). The sRR (95 % CI) of AMI for sulfonylurea versus metformin was 1.24 (1.14–1.34) [I2 = 41 %] and for pioglitazone versus metformin was 1.02 (0.75–1.38) [I2 = 17 %]. Sensitivity analyses decreased heterogeneity in most comparisons.Conclusion/interpretationSulfonylureas increased the risk of AMI by 24 % compared with metformin; an imprecise point estimate indicated no difference in risk of AMI when comparing pioglitazone with metformin. The presence of heterogeneity precluded any conclusions on the other comparisons. The quality assessment was valuable in identifying methodological problems in the individual studies and for analysing potential sources of heterogeneity.

【 授权许可】

CC BY   
© Pladevall et al. 2016