Evaluation of focal cartilage lesions of the knee using MRI T2 mapping and delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC)

BMC Musculoskeletal Disorders

Research Article

Jan Harald Røtterud¹  Asbjørn Årøen²  Einar Andreas Sivertsen³  Helga Brøgger⁴  May Arna Risberg⁵  Lars Engebretsen⁶ 

[1] Department of Orthopedic Surgery, Akershus University Hospital, 1478, Lørenskog, Norway;Department of Orthopedic Surgery, Akershus University Hospital, 1478, Lørenskog, Norway;Oslo Sports Trauma Research Center, The Norwegian School of Sport Sciences, Pb 4014 Ullevål Stadion, Oslo, Norway;Institute of Clinical Medicine, Campus Ahus, University of Oslo, 1478, Lørenskog, Norway;Department of Orthopedic Surgery, Diakonhjemmet Hospital, Pb 23, Vindern, 0319, Oslo, Norway;Department of Radiology, Oslo University Hospital Ullevål, Kirkeveien 166, 0450, Oslo, Norway;Norwegian Research Center for Active Rehabilitation, Department of Orthopedic Surgery, Oslo University Hospital Ullevål, Kirkeveien 166, 0450, Oslo, Norway;Oslo Sports Trauma Research Center, The Norwegian School of Sport Sciences, Pb 4014 Ullevål Stadion, Oslo, Norway;Department of Orthopedic Surgery, Oslo University Hospital Ullevål, Kirkeveien 166, 0450, Oslo, Norway;

关键词: Knee;    Cartilage lesion;    MRI;    dGEMRIC;    T2-mapping;   

DOI  :  10.1186/s12891-016-0941-y

 received in 2015-06-13, accepted in 2016-02-10,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundAssessment of degenerative changes of the cartilage is important in knee cartilage repair surgery. Magnetic Resonance Imaging (MRI) T2 mapping and delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) are able to detect early degenerative changes. The hypothesis of the study was that cartilage surrounding a focal cartilage lesion in the knee does not possess degenerative changes.MethodsTwenty-eight consecutive patients included in a randomized controlled trial on cartilage repair were evaluated using MRI T2 mapping and dGEMRIC before cartilage treatment was initiated. Inclusion was based on disabling knee problems (Lysholm score of ≤ 75) due to an arthroscopically verified focal femoral condyle cartilage lesion. Furthermore, no major malalignments or knee ligament injuries were accepted. Mean patient age was 33 ± 9.6 years, and the mean duration of knee symptoms was 49 ± 60 months. The MRI T2 mapping and the dGEMRIC measurements were performed at three standardized regions of interest (ROIs) at the medial and lateral femoral condyle, avoiding the cartilage lesionResultsThe MRI T2 mapping of the cartilage did not demonstrate significant differences between condyles with or without cartilage lesions. The dGEMRIC results did not show significantly lower values of the affected condyle compared with the opposite condyle and the contra-lateral knee in any of the ROIs. The intraclass correlation coefficient (ICC) of the dGEMRIC readings was 0.882.ConclusionThe MRI T2 mapping and the dGEMRIC confirmed the arthroscopic findings that normal articular cartilage surrounded the cartilage lesion, reflecting normal variation in articular cartilage quality.Study identifierNCT00885729, registered April 17 2009.

【 授权许可】

CC BY   
© Årøen et al. 2016