Regulation of gene expression in human tendinopathy

BMC Musculoskeletal Disorders

Research Article

Lawrence V Gulotta¹  Scott A Rodeo¹  Howard J Seeherman²  Scott A Jelinsky²  Jian Li²  Joanne M Archambault² 

[1] Section of Shoulder & Sports Medicine, Laboratory for Soft Tissue Research, Hospital for Special Surgery, 535 East 70th Street, 10021, New York City, NY, USA;Tissue Repair, Pfizer Research, 200 Cambridge Park Drive, 02140, Cambridge, MA, USA;

关键词: Rotator Cuff;    Supraspinatus Tendon;    Tendon Healing;    Achilles Tendinopathy;    Patella Tendinopathy;   

DOI  :  10.1186/1471-2474-12-86

 received in 2010-12-17, accepted in 2011-05-03,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundChronic tendon injuries, also known as tendinopathies, are common among professional and recreational athletes. These injuries result in a significant amount of morbidity and health care expenditure, yet little is known about the molecular mechanisms leading to tendinopathy.MethodsWe have used histological evaluation and molecular profiling to determine gene expression changes in 23 human patients undergoing surgical procedures for the treatment of chronic tendinopathy.ResultsDiseased tendons exhibit altered extracellular matrix, fiber disorientation, increased cellular content and vasculature, and the absence of inflammatory cells. Global gene expression profiling identified 983 transcripts with significantly different expression patterns in the diseased tendons. Global pathway analysis further suggested altered expression of extracellular matrix proteins and the lack of an appreciable inflammatory response.ConclusionsIdentification of the pathways and genes that are differentially regulated in tendinopathy samples will contribute to our understanding of the disease and the development of novel therapeutics.

【 授权许可】

CC BY   
© Jelinsky et al; licensee BioMed Central Ltd. 2011