Exploring the presence of narcolepsy in patients with schizophrenia

BMC Psychiatry

Research Article

Roser Casamitjana¹  Guadalupe Ercilla²  Joan Santamaria³  Carles Gaig³  Alex Iranzo³  Gemma Sansa⁴  Gisela Ribera⁴  Alba Gavaldà⁵  José Monreal⁶ 

[1] Biochemistry and Molecular Genetics Laboratory, Centre de Diagnòstic Biomèdic (CDB), Hospital Clínic of Barcelona, Barcelona, Spain;Immunology Laboratory, Hospital Clínic of Barcelona, Barcelona, Spain;Neurology Service and Multidisciplinary Sleep Disorders Unit, Hospital Clínic of Barcelona, Barcelona, Spain;Neurology Service and Multidisciplinary Sleep Disorders Unit, Hospital Parc Taulí, Sabadell, Spain;Neuropsychology Department, Neurology Service. Hospital Parc Taulí, Sabadell, Spain;Psychiatry Service, Hospital Parc Taulí, Sabadell, Spain;

关键词: Hallucinations;    Narcolepsy;    Hypocretin;    Psychotic disorders;    Schizophrenia;   

DOI  :  10.1186/s12888-016-0859-9

 received in 2015-10-27, accepted in 2016-05-10,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThere are several case reports of patients with narcolepsy and schizophrenia, but a systematic examination of the association of both disorders has not been done. The aim of this work is to assess the frequency of narcolepsy with cataplexy in a large consecutive series of adult patients with schizophrenia and schizoaffective disorder.MethodsWe screened 366 consecutive patients with schizophrenia or schizoaffective disorder with a sleep questionnaire and the Epworth Sleepines scale (ESS) exploring narcoleptiform symptoms. Those who screened positive were assessed by a sleep specialist, and offered an HLA determination. CSF hypocretin-1 determination was proposed to those who were HLA DQB1*06:02 positive.ResultsOn the screening questionnaire, 17 patients had an ESS score ≥11 without cataplexy, 15 had cataplexy-like symptoms with an ESS score < 11, and four had an ESS score ≥11 plus cataplexy-like symptoms. Of those, 24 patients were evaluated by a sleep specialist. Five of these 24 were HLA DQB1*06:02 positive, and three of these five subjects underwent lumbar puncture showing normal hypocretin-1 levels.ConclusionsOur results suggest that narcolepsy with cataplexy is not an unrecognized disease in adult patients with schizophrenia or schizoaffective disorder.

【 授权许可】

CC BY   
© Sansa et al. 2016