BMC Psychiatry | |
Exploring the presence of narcolepsy in patients with schizophrenia | |
Research Article | |
Roser Casamitjana1  Guadalupe Ercilla2  Joan Santamaria3  Carles Gaig3  Alex Iranzo3  Gemma Sansa4  Gisela Ribera4  Alba Gavaldà5  José Monreal6  | |
[1] Biochemistry and Molecular Genetics Laboratory, Centre de Diagnòstic Biomèdic (CDB), Hospital Clínic of Barcelona, Barcelona, Spain;Immunology Laboratory, Hospital Clínic of Barcelona, Barcelona, Spain;Neurology Service and Multidisciplinary Sleep Disorders Unit, Hospital Clínic of Barcelona, Barcelona, Spain;Neurology Service and Multidisciplinary Sleep Disorders Unit, Hospital Parc Taulí, Sabadell, Spain;Neuropsychology Department, Neurology Service. Hospital Parc Taulí, Sabadell, Spain;Psychiatry Service, Hospital Parc Taulí, Sabadell, Spain; | |
关键词: Hallucinations; Narcolepsy; Hypocretin; Psychotic disorders; Schizophrenia; | |
DOI : 10.1186/s12888-016-0859-9 | |
received in 2015-10-27, accepted in 2016-05-10, 发布年份 2016 | |
来源: Springer | |
【 摘 要 】
BackgroundThere are several case reports of patients with narcolepsy and schizophrenia, but a systematic examination of the association of both disorders has not been done. The aim of this work is to assess the frequency of narcolepsy with cataplexy in a large consecutive series of adult patients with schizophrenia and schizoaffective disorder.MethodsWe screened 366 consecutive patients with schizophrenia or schizoaffective disorder with a sleep questionnaire and the Epworth Sleepines scale (ESS) exploring narcoleptiform symptoms. Those who screened positive were assessed by a sleep specialist, and offered an HLA determination. CSF hypocretin-1 determination was proposed to those who were HLA DQB1*06:02 positive.ResultsOn the screening questionnaire, 17 patients had an ESS score ≥11 without cataplexy, 15 had cataplexy-like symptoms with an ESS score < 11, and four had an ESS score ≥11 plus cataplexy-like symptoms. Of those, 24 patients were evaluated by a sleep specialist. Five of these 24 were HLA DQB1*06:02 positive, and three of these five subjects underwent lumbar puncture showing normal hypocretin-1 levels.ConclusionsOur results suggest that narcolepsy with cataplexy is not an unrecognized disease in adult patients with schizophrenia or schizoaffective disorder.
【 授权许可】
CC BY
© Sansa et al. 2016
【 预 览 】
Files | Size | Format | View |
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RO202311094384430ZK.pdf | 615KB | download |
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