Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study

BMC Infectious Diseases

Research Article

Demócrito B Miranda Filho¹  Magda Maruza²  Isabella Coimbra²  Ulisses R Montarroyos²  Heloísa R Lacerda²  Líbia V Moura²  Ricardo AA Ximenes³  Laura C Rodrigues⁴  Maria FP Militão Albuquerque⁵ 

[1] Department of Medical Science, Universidade de Pernambuco, Recife, Brazil;Department of Tropical Medicine, Universidade Federal de Pernambuco, Recife, Brazil;Department of Tropical Medicine, Universidade Federal de Pernambuco, Recife, Brazil;Department of Medical Science, Universidade de Pernambuco, Recife, Brazil;London School of Hygiene and Tropical Medicine, London, UK;NESC Department, Centro de Pesquisas Aggeu Magalhães/FIOCRUZ, Recife, Brazil;

关键词: Human Immunodeficiency Virus;    Human Immunodeficiency Virus Patient;    Directly Observe Therapy;    Final Multivariate Model;    Treatment Default;   

DOI  :  10.1186/1471-2334-11-351

 received in 2010-12-13, accepted in 2011-12-16,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundConcomitant treatment of Human Immunodeficiency Virus (HIV) infection and tuberculosis (TB) presents a series of challenges for treatment compliance for both providers and patients. We carried out this study to identify risk factors for default from TB treatment in people living with HIV.MethodsWe conducted a cohort study to monitor HIV/TB co-infected subjects in Pernambuco, Brazil, on a monthly basis, until completion or default of treatment for TB. Logistic regression was used to calculate crude and adjusted odds ratios, 95% confidence intervals and P-values.ResultsFrom a cohort of 2310 HIV subjects, 390 individuals (16.9%) who had started treatment after a diagnosis of TB were selected, and data on 273 individuals who completed or defaulted on treatment for TB were analyzed. The default rate was 21.7% and the following risk factors were identified: male gender, smoking and CD4 T-cell count less than 200 cells/mm3. Age over 29 years, complete or incomplete secondary or university education and the use of highly active antiretroviral therapy (HAART) were identified as protective factors for the outcome.ConclusionThe results point to the need for more specific actions, aiming to reduce the default from TB treatment in males, younger adults with low education, smokers and people with CD4 T-cell counts < 200 cells/mm3. Default was less likely to occur in patients under HAART, reinforcing the strategy of early initiation of HAART in individuals with TB.

【 授权许可】

CC BY   
© Maruza et al; licensee BioMed Central Ltd. 2011