Semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts of the knee at 3T MRI: A comparison between intermediate-weighted fat-suppressed spin echo and Dual Echo Steady State sequences

BMC Musculoskeletal Disorders

Research Article

John M Jakicic¹  Michael J Hannon²  Stephanie M Green²  C Kent Kwoh³  Frank W Roemer⁴  Daichi Hayashi⁴  Ali Guermazi⁵  Carolyn Moore⁶ 

[1] Department of Health and Physical Activity, University of Pittsburgh, 15260, Pittsburgh, PA, USA;Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, 15261, Pittsburgh, PA, USA;Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, 15261, Pittsburgh, PA, USA;Pittsburgh VA Healthcare System, 15240, Pittsburgh, PA, USA;Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, 02118, Boston, MA, USA;Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, 02118, Boston, MA, USA;Department of Radiology, Klinikum Augsburg, Augsburg, Germany;Texas Woman's University, 77030, Houston, TX, USA;

关键词: bone marrow lesion;    cyst;    MRI;    knee;    osteoarthritis;   

DOI  :  10.1186/1471-2474-12-198

 received in 2011-06-14, accepted in 2011-09-09,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundChoice of appropriate MR pulse sequence is important for any research studies using imaging-derived data. The aim of this study was to compare semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts using intermediate-weighted (IW) fat-suppressed (fs) spin echo and Dual Echo Steady State (DESS) sequences on 3 T MRI.MethodsIncluded were 201 subjects aged 35-65 with frequent knee pain. 3T MRI was performed with the same sequence protocol as in the Osteoarthritis Initiative (OAI). In a primary reading subchondral bone marrow edema-like lesions were assessed according to the WORMS system. Two hundred subregions with such lesions were randomly chosen. The extent of subchondral bone marrow edema-like lesions was re-evaluated separately using sagittal IW fs and DESS sequences according to WORMS. Lesion size and confidence of the differentiation between subchondral bone marrow edema-like lesions and subchondral cysts located within or adjacent to them was rated from 0 to 3. Wilcoxon signed-rank tests and chi-square statistics were used to examine differences between the two sequences.ResultsOf 200 subchondral bone marrow edema-like lesions detected by IW fs sequence, 93 lesions (46.5%) were not depicted by the DESS sequence. The IW fs sequence depicted subchondral bone marrow edema-like lesions to a larger extent than DESS (p < 0.0001), and the opposite was true for subchondral cysts. Confidence scores for differentiation of the two types of lesions were not significantly different between the two sequences.ConclusionsIn direct comparison the IW fs sequence depicts more subchondral bone marrow edema-like lesions and better demonstrate the extent of their maximum size. The DESS sequence helps in the differentiation of subchondral bone marrow edema-like lesions and subchondral cysts. The IW fs sequence should be used for determination of lesion extent whenever the size of subchondral bone marrow edema-like lesions is the focus of attention.

【 授权许可】

CC BY   
© Hayashi et al; licensee BioMed Central Ltd. 2011