Sero-epidemiological assessment of Chlamydia trachomatis infection and sub-fertility in Samoan women

BMC Infectious Diseases

Research Article

M. Walsh¹  P. C. Hill¹  A. A. Righarts¹  S. V. A. Temese²  P. Timms³  S. H. Stansfield⁴  S. Menon⁴  W. M. Huston⁵  L. Isaia⁶  L. Auvaa⁷  E. Hope⁷  S. A. Tapelu⁸  T. Niupulusu⁹  L. Iosefa-Siitia^1,10  M. F. Motu^1,10  T. Suaalii-Sauni^1,11 

[1] Centre for International Health, University of Otago, Dunedin, New Zealand;Centre for Samoan Studies, National University of Samoa, Apia, Samoa;Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, Australia;Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia;Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia;School of Life Sciences, Faculty of Science, University of Technology Sydney, Broadway, Sydney, NSW, Australia;School of Life Sciences, University of Technology Sydney, PO BOX 123, Broadway, 2007, Sydney, NSW, Australia;National Health Service Laboratory Division, Apia, Samoa;National University of Samoa, Apia, Samoa;Samoa AIDS Foundation, Apia, Samoa;Samoa Family Health Association, Apia, Samoa;Samoa National Council of Churches, Apia, Samoa;Victoria University of Wellington, Wellington, New Zealand;

关键词: Chlamydia;    Pacific islands;    samoa;    female sub-fertility;    diagnosis;    serology;   

DOI  :  10.1186/s12879-016-1508-0

 received in 2015-10-08, accepted in 2016-04-13,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundIn our recent village-based cross-sectional study, the prevalence of nucleic acid amplification technique (NAAT) diagnosed Chlamydia trachomatis (CT) in sexually active Samoan women was very high (36 %), and test positivity was associated with sub-fertility. We conducted a serological and epidemiological analysis in these participants to identify if serological data can provide further insight into the potential contribution of CT to sub-fertility in this population.MethodsSerological prediction of CT associated sub-fertility was conducted using a series of commercial tests. The correlation between fertility or sub-fertility, behavioral factors, and serologically predicted CT associated sub-fertility was determined.ResultsA positive antibody reaction against the Chlamydia Major Outer Membrane Protein (MOMP) was significantly associated with sub-fertility, with 50 % of infertile women being positive. Serum IgG and IgA antibodies against MOMP correlated with current infection measured by urine NAAT, suggesting longer term infections are common in this population. Chlamydia pneumoniae antibodies were frequently detected in this population (84 %), and unexpectedly, were significantly associated with sub-fertility.ConclusionsThe high prevalence of chlamydial infection and of positive chlamydial sub-fertility results suggests that CT is an important and frequent contributory factor to sub-fertility in this population.

【 授权许可】

CC BY   
© Menon et al. 2016