Evaluation of therapeutic potential of VB-001, a leave-on formulation, for the treatment of moderate adherent dandruff

BMC Dermatology

Research Article

Shiladitya Sengupta¹  Shamik Ghosh²  Sudhanand Prasad²  Nilu Jain²  Anamika Bhattacharyya²  Shilpi Jain²  Vishal Yadav² 

[1] Medicine & HST, Brigham and Women’s Hospital, Harvard Medical School, Room 317, 65 Landsdowne Street, 02139, Cambridge, MA, USA;Vyome Biosciences Pvt. Ltd, Plot# 465, F.I.E., Patparganj Industrial Area, 110092, Delhi, India;

关键词: Scalp;    Dandruff;    Malassezia;    Anti-fungals;   

DOI  :  10.1186/s12895-017-0058-5

 received in 2016-09-09, accepted in 2017-04-25,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundDandruff is a common scalp condition characterized by excessive scaling and itch. Aberrant colonization of the scalp by commensal Malassezia spp. is a major contributor in the multifactorial etiology of dandruff. Literature based understanding of Malassezia linked pathophysiology of dandruff allowed us to comprehend a strategy to potentiate the efficacy of a known antifungal agent used in dandruff therapy.The aim of this study was to determine the efficacy and skin safety of VB-001 antidandruff leave-on formulation in comparison with marketed antidandruff ZPTO shampoo in patients with moderate adherent dandruff of the scalp.MethodsHealthy males or females aged ≥ 15 years and ≤ 65 with a clinical diagnosis of moderate adherent dandruff of the scalp were recruited for the study to monitor the effects of topical VB-001 versus those of marketed antidandruff ZPTO shampoo.Results168 subjects were randomized to the treatment (VB-001, n = 84) and control (ZPTO shampoo, n = 84) groups. The efficacy of each product was evaluated by comparing proportion of subjects who have shown reduction in flaking by ASFS (adherent scalp flaking score) and pruritus by IGA (investigator global assessment) score. VB-001 imparted consistently better reduction in ASFS and enabled early reduction of pruritus in comparison to marketed ZPTO shampoo.ConclusionVB-001, a leave-on formulation with ingredients chosen to selectively disturb the Malassezia niche on dandruff scalp by denying extra nutritional benefits to the microbe, provides unique advantages over existing best in class ZPTO shampoo therapy. It has the potential to emerge as an attractive novel treatment for moderate adherent dandruff.Trial registrationCTRI Registration number: CTRI/2013/01/003283. Registered on: 02/01/2013

【 授权许可】

CC BY   
© The Author(s). 2017