Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy

BMC Microbiology

Research Article

Pei-Ying Hong¹  Kaw Yan Chua²  Bee Wah Lee²  Kok Keong Chee²  Marion Aw²  Lynette Pei-Chi Shek²  Gaik Chin Yap²  Yati Soenarto³  Cahya D Satria³  Ekawaty L Haksari³  Christophe Lay⁴  Yudong Zhao⁵  Doreen Leow⁵ 

[1] Department of Animal Sciences, University of Illinois, West Gregory Drive, 61801, Urbana, Champaign, USA;Department of Paediatrics, National University of Singapore, Medical Drive, 117597, Singapore, Singapore;Faculty of Medicine, Gadjah Mada University, 55284, Jalan Kesehatan, Yogyakarta, Indonesia;Genome Institute of Singapore, Biopolis Street, 138672, Singapore, Singapore;Singapore Clinical Research Institute, Biopolis Way, 138669, Singapore, Singapore;

关键词: Terminal Restriction Fragment Length Polymorphism;    Bacterial Group;    Fecal Microbiota;    Terminal Restriction Fragment Length Polymorphism Analysis;    Sibship Size;   

DOI  :  10.1186/1471-2180-11-193

 received in 2011-05-08, accepted in 2011-08-26,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundStudies have suggested that demographic and lifestyle factors could shape the composition of fecal microbiota in early life. This study evaluated infant stool microbiota signatures in two Asian populations, Singapore (n = 42) and Indonesia (n = 32) with contrasting socioeconomic development, and examined the putative influences of demographic factors on these human fecal associated bacterial signatures.ResultsLongitudinal analysis showed associations of geographical origin with Clostridium leptum, Atopobium and Bifidobacterium groups. Mode of delivery had the largest effect on stool microbiota signatures influencing the abundance of four bacterial groups. Significantly higher abundance of bacterial members belonging to the Bacteroides-Prevotella, Bifidobacterium and Atopobium groups, but lower abundance of Lactobacilli-Enterococci group members, were observed in vaginal delivered compared to caesarean delivered infants. Demographic factors influencing the structure of infants stool microbiota during the first year of life included breastfeeding, age of weaning, sibship size and exposure to antibiotics.ConclusionsDifferences in stool microbiota signatures were observed in relation to various demographic factors. These features may confound studies relating to the association of the structure of fecal microbiota and the predisposition to human modern disease.

【 授权许可】

Unknown   
© Yap et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.