BMC Infectious Diseases | |
A longitudinal study of allergy and intestinal helminth infections in semi urban and rural areas of Flores, Indonesia (ImmunoSPIN Study) | |
Study Protocol | |
Iwan Ariawan1  Ronald van Ree2  Hae Won Uh3  Firdaus Hamid4  Sitti Wahyuni5  Taniawati Supali6  Heri Wibowo6  Yenny Djuardi6  Linda J Wammes7  Linda May7  Erliyani Sartono7  Maria Yazdanbakhsh7  Jaco J Verweij7  Maria MM Kaisar8  Aprilianto E Wiria8  Robert Schot9  Bertrand Lell1,10  | |
[1] Department of Biostatistics, School of Public Health, University of Indonesia, Jakarta, Indonesia;Department of Experimental Immunology and Department of Otorhinolaryngology, Academic Medical Center, Amsterdam University, Amsterdam, The Netherlands;Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands;Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia;Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands;Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia;Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia;Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands;Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands;Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia;Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands;Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; | |
关键词: Atopic Dermatitis; Allergic Disease; Skin Prick Test; Helminth Infection; Allergic Disorder; | |
DOI : 10.1186/1471-2334-11-83 | |
received in 2011-01-19, accepted in 2011-04-01, 发布年份 2011 | |
来源: Springer | |
【 摘 要 】
BackgroundThe prevalence of asthma and atopic disease has been reported to be low in low income countries, however helminth infections are likely to be high among these communities. The question of whether helminth infections play a role in allergic diseases can best be addressed by intervention studies. None of the studies so far have been based on a large scale placebo-controlled trial.Method/DesignThis study was designed to assess how intestinal helminth infections can influence the immune response and atopic and allergic disorders in children in Indonesia. The relations between allergic outcomes and infection and lifestyle factors will be addressed. This study was set up among school-age children in semi urban and rural areas, located in Ende District of Flores Island, Indonesia. A randomized placebo-controlled anthelmintic treatment trial to elucidate the impact of helminth infections on the prevalence of skin prick test (SPT) reactivity and symptoms of allergic diseases will be performed. The children living in these semi-urban and rural areas will be assessed for SPT to allergens before and after 1 and 2 years of treatment as the primary outcome of the study; the secondary outcome is symptoms (asthma and atopic dermatitis); while the tertiary outcome is immune responses (both antibody levels to allergens and cellular immune responses).DiscussionThe study will provide information on the influence of helminth infections and anthelmintic treatment on immune response, atopy and allergic disorders.Trial registrationCurrent Controlled Trials ISRCTN: ISRCTN83830814
【 授权许可】
Unknown
© Hamid et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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