Weight change during chemotherapy in breast cancer patients: a meta-analysis

BMC Cancer

Research Article

H.W.M van Laarhoven¹  J.Th.C.M. de Kruif²  M. Visser³  R.M. Winkels⁴  J.H.M. de Vries⁴  E. Kampman⁴  M.M.G.A. van den Berg⁴  Y.C. de Vries⁵ 

[1] Academic Medical Center, Medical Oncology, Meibergdreef 9, F4-224, 1105, Amsterdam, AZ, The Netherlands;Department of Health Sciences, VU University Amsterdam, De Boelelaan 1085, 1081, Amsterdam, HV, The Netherlands;Department of Health Sciences, VU University Amsterdam, De Boelelaan 1085, 1081, Amsterdam, HV, The Netherlands;Department of Internal Medicine, Nutrition and Dietetics, VU University Medical Center, De Boelelaan 1117, 1007, Amsterdam, MB, The Netherlands;Division of Human Nutrition, Wageningen University, Stippeneng 4, 6708, Wageningen, WE, The Netherlands;Division of Human Nutrition, Wageningen University, Stippeneng 4, 6708, Wageningen, WE, The Netherlands;Top Institute Food and Nutrition, Nieuwe Kanaal 9A, 6709, Wageningen, PA, The Netherlands;

关键词: Breast cancer;    Chemotherapy;    Weight change;    Meta-analysis;   

DOI  :  10.1186/s12885-017-3242-4

 received in 2016-05-04, accepted in 2017-03-29,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundWeight gain during chemotherapy in women with breast cancer is commonly reported.However, there are important differences between studies that examined weight change during chemotherapy; e.g. type of chemotherapy, menopausal status, time between body weight measurements and sample size. The purpose of this meta-analysis was to quantify changes in body weight during chemotherapy for women with breast cancer, taking these differences into account.MethodsWe identified relevant studies using PubMed, Scopus and Embase databases. The search was limited to human studies published in English up to and including December 2015. Only studies among women with early stage breast cancer treated with chemotherapy, with reported body weight before and after chemotherapy and type of chemotherapy were included. Random-effect models were used, and heterogeneity between studies was explored through stratified analyses and meta-regression. Sensitivity analyses were done to explore whether a specific study markedly affected the results.ResultsIn total 25 papers were found, including data from 2620 women. Overall, body weight increased during chemotherapy: 2.7 kg (95% CI 2.0, 7.5) with a high degree of heterogeneity (I2 = 94.2%). Stratified analyses showed weight gain in all strata, but did not substantially reduce heterogeneity. Univariate meta-regression showed less weight gain in prospective studies compared to chart review studies (−2.0, 95% CI: -3.1, −0.8). Studies including cyclophosphamide, methotrexate and 5-fluorouracil (CMF) regimes showed a greater weight gain compared to those that did not (2.2, 95% CI: 1.1, 3.3); and papers published until the year 2000 showed a greater weight gain compared to those published after 2000 (1.9, 95% CI:-0.8, 3.1). In the multivariate models only studies including CMF regimes and studies published until 2000 were associated with significant weight gain of respectively 1.3 and 1.4 kg.ConclusionDespite the high heterogeneity, this meta-analysis shows significant weight gain during chemotherapy for women with breast cancer. Weight gain was more pronounced in papers published until 2000 and women receiving CMF as chemotherapy regime. Although weight gain after chemotherapy has decreased over the course of time, weight gain is still substantial and deserves clinical attention.

【 授权许可】

CC BY   
© The Author(s). 2017