Tachykinin receptors antagonism for asthma: a systematic review

BMC Pulmonary Medicine

Research Article

Raquel Soares¹  Renata Ramalho²  André Moreira³  Nuno Couto⁴ 

[1] Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal;Department of Immunology, Faculty of Medicine, University of Porto, Porto, Portugal;Centro de Dermatologia Epidermis, Instituto CUF, Porto, Portugal;Department of Immunology, Faculty of Medicine, University of Porto, Porto, Portugal;Department of Immunoallergology, Hospital of São João E.P.E, Porto, Portugal;Portuguese Oncology Institute IPOPFG-E.P.E, Porto, Portugal;

关键词: Asthma;    Airway Inflammation;    Chest Tightness;    Improve Lung Function;    Tachykinin Receptor;   

DOI  :  10.1186/1471-2466-11-41

 received in 2010-08-25, accepted in 2011-08-02,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTachykinins substance P, neurokinin A and neurokinin B seem to account for asthma pathophysiology by mediating neurogenic inflammation and several aspects of lung mechanics. These neuropeptides act mainly by their receptors NK1, NK2 and NK3, respectively which may be targets for new asthma therapy.MethodsThis review systematically examines randomized controlled trials evaluating the effect of tachykinins receptors antagonism on asthma. Symptoms, airway inflammation, lung function and airway inflammation were considered as outcomes. We searched the Cochrane Airways Group Specialized Register of Asthma Trials, Cochrane Database of Systematic Reviews, MEDLINE/PubMed and EMBASE. The search is as current as June 2010. Quality rating of included studies followed the Cochrane Collaboration and GRADE Profiler approaches. However, data were not pooled together due to different measures among the studies.ResultsOur systematic review showed the potential of NK receptor antagonist to decrease airway responsiveness and to improve lung function. However, effects on airway inflammation and asthma symptoms were poorly or not described.ConclusionThe limited available evidence suggests that tachykinin receptors antagonists may decrease airway responsiveness and improve lung function in patients with asthma. Further large randomized trials are still required.

【 授权许可】

CC BY   
© Ramalho et al; licensee BioMed Central Ltd. 2011