The fusion rate of demineralized bone matrix compared with autogenous iliac bone graft for long multi-segment posterolateral spinal fusion

BMC Musculoskeletal Disorders

Research Article

Tsai-Sheng Fu¹  I-Chun Wang¹  Wen-Jer Chen²  Lih-Huei Chen²  Meng-Ling Lu²  Ming-Kai Hsieh² 

[1] Department of Orthopaedic Surgery, Chang Gung Memorial Hospital in Keelung, School of Medicine, Chang Gung University, Taoyuan, Taiwan;Department of Orthopaedic Surgery, Chang Gung Memorial Hospital in Linkou, School of Medicine, Chang Gung University, Taoyuan, Taiwan;

关键词: Multi-segment posterolateral fusion;    Demineralized bone matrix;    Bone graft substitute;    Autogenous iliac bone graft;    Osteoconduction;    Osteoinduction;    Osteogenesis;   

DOI  :  10.1186/s12891-015-0861-2

 received in 2015-08-08, accepted in 2015-12-23,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundAlthough autogenous iliac bone graft (AIBG) remains the gold standard for spine fusion, harvesting morbidity has prompted the search for alternatives especially for multi-segment fusion. This study aimed to evaluate the efficacy of using demineralized bone matrix (DBM) as a substitute of AIBG for long instrumented posterolateral fusion (≧ three-level fusion).MethodsA total of 47 consecutive patients underwent laminectomy decompression, and multi-level instrumented posterolateral fusions were reviewed. Group 1 comprised 26 patients having DBM with autologous laminectomy bone (ALB). Group 2 consisted of 21 patients having AIBG with ALB. The fusion success evaluation was based on findings using the 12-month anteroposterior and dynamic plain radiographs.ResultsGender, age, and the number of fusion levels were similar for both groups. 21 of 26 (80.8 %) patients in group 1 and 18 of 21 (85.7 %) patients in group 2 were observed to achieve solid bony fusion. There was no statistical difference in the fusion success (p = 0.72). Blood loss was significantly more in group 2 (p = 0.02). The duration of the hospital stays and operative times being longer for group 2, but the difference was not significant.ConclusionsDBM combined with ALB and osteoconductive materials is as effective as an autologous iliac bone graft with respect to long multi-segment posterolateral fusion success. DBM can be used as an effective bone graft substitute and may decrease morbidities associated with iliac bone graft harvest.

【 授权许可】

CC BY   
© Fu et al. 2016