Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma

BMC Cancer

Research Article

Zhonghua Li¹  Sheng Han¹  Yang Liu¹  Anhua Wu¹  Haipei Hou¹  Qingchang Li² 

[1] Department of Neurosurgery, The First Hospital of China Medical University, Nanjing Street 155, Heping District, 110001, Shenyang, China;Department of Pathology, China Medical University, 110001, Shenyang, China;

关键词: Overall Survival;    Karnofsky Performance Status;    Neutrophil Infiltration;    Absolute Lymphocyte Count;    MGMT Promoter Methylation;   

DOI  :  10.1186/s12885-015-1629-7

 received in 2015-04-30, accepted in 2015-08-27,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundMarkers of systemic inflammation are correlated with patient survival in various cancers. The prognostic value of neutrophil-to-lymphocyte ratio (NLR) was compared with that of platelet-to-lymphocyte ratio (PLR) in patients with glioblastoma. The association of NLR with neutrophil and T- cell infiltration was also explored.MethodsA total of 152 patients with glioblastoma were retrospectively analyzed. Clinical information was obtained from electronic medical records. Kaplan-Meier analysis and the Cox proportional hazards models were used to examine the survival function of pre-treatment NLR and PLR in these glioblastoma patients. Neutrophil and CD3+ T-cell infiltration was assessed by immunohistochemical staining of tissue microarray cores from glioblastomas.ResultsPre-treatment NLR levels were significantly correlated with overall survival (OS) in glioblastoma patients (multivariate hazard ratio =1.050; 95 % confidence interval, 1.003–1.100; P = 0.037). Despite the correlation between NLR and PLR (R = 0.509, P < 0.001), NLR was superior to PLR as a prognostic factor. High pre-treatment NLR (≥4 versus < 4) was significantly associated with high neutrophil infiltration and low CD3+ T-cell infiltration into tumors, and predicted poor OS (mean, 10.6 vs. 17.9 months, P < 0.001).ConclusionsPre-treatment NLR is of prognostic significance independent of MGMT status and is superior to PLR as a prognostic factor. Our results demonstrate a correlation between elevated peripheral blood NLR levels and increased tumor neutrophil infiltration/decreased CD3+ T-cell infiltration.

【 授权许可】

CC BY   
© Han et al. 2015