Periodontal disease-associated micro-organisms in peri-menopausal and post-menopausal women using or not using hormone replacement therapy. A two-year follow-up study

BMC Oral Health

Research Article

Aila Tiitinen¹  Laura Tarkkila²  Kirsti Kari²  Jussi Furuholm³  Jukka H Meurman³ 

[1] Department of Obstetrics and Gynaecology, University Central Hospital, Helsinki, Finland;Institute of Dentistry, University of Helsinki, Helsinki, Finland;Institute of Dentistry, University of Helsinki, Helsinki, Finland;Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital, Helsinki, Finland;

关键词: Hormone Replacement Therapy;    Oral Health;    Oral Health Status;    Periodontal Pathogen;    Deep Pocket;   

DOI  :  10.1186/1472-6831-10-10

 received in 2009-10-11, accepted in 2010-04-29,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundDespite conflicting results on the use of hormone replacement therapy (HRT) there is no doubt that many women benefit from it. Women using HRT are known to be more health conscious in general with putative positive implications in the mouth. However, we observed recently in our cohort hardly any difference in oral health status between HRT-users and non-users. There are only a few studies about HRT and oral microbiota. We hypothesized that counts of periodontal micro-organisms are lower in health-conscious HRT-users than non-users.MethodsTwo-year open follow-up study was conducted on originally 200 HRT-users and 200 non-users from age cohorts of 50-58 years. After clinical examination pooled subgingival plaque samples were taken for polymerase chain reaction analyses. The results of finally 135 women meeting the inclusion criteria were analyzed with cross-tabulation and chi-square test. Explanatory factors were studied by step-wise logistic regression analysis.ResultsIn HRT group, the numbers of positive samples for Porphyromonas gingivalis (P. gingivalis, p < 0.07), Prevotella intermedia (P. intermedia, p < 0.05)and Tannerella forsythia (T. forsythia, p < 0.01) decreased in women with ≥ 4-mm-deep pockets. Respectively in HRT users with ≥ 6-mm-deep pockets the numbers of positive samples for P. gingivalis (p < 0.05) and T. forsythia (p < 0.01) were decreased. No corresponding differences were observed in the non-HRT group. In logistic regression, the existence of deep periodontal pockets explained the majority of cases harboring specific micro-organisms in both groups.ConclusionAlthough use of HRT did not correlate with periodontal health status, HRT led to decreasing numbers of positive samples of the periodontal pathogens P. gingivalis and T. forsythia. Further studies with longer observation time are needed to observe the clinical relevance of the results.

【 授权许可】

CC BY   
© Tarkkila et al; licensee BioMed Central Ltd. 2010