COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data

BMC Cancer

Research Article

Joey S. W. Kwong¹  Jian-Gang Chen²  Xiu-Jie Wen³  Wei-Dong Leng⁴  Xian-Tao Zeng⁵  Wei Huang⁶ 

[1] Chinese Cochrane Center, Chinese Evidence-Based Medicine Center, Western China Hospital, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Stomatology, Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, 169 Donghu Road, 430071, Wuhan, China;Department of Stomatology, Daping Hospital & Research Institute of Surgery, Third Military Medical University, 400042, Chongqing, China;Department of Stomatology, Taihe Hospital, Institute of Oral and Maxillofacial Surgery, Hubei University of Medicine, 442000, Shiyan, China;Department of Stomatology, Taihe Hospital, Institute of Oral and Maxillofacial Surgery, Hubei University of Medicine, 442000, Shiyan, China;Department of Stomatology, Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, 169 Donghu Road, 430071, Wuhan, China;Department of Stomatology, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, 519000, Zhuhai, China;

关键词: COX-2 rs689466;    COX-2 rs5275;    COX-2 rs20417;    Polymorphism;    Head and neck squamous cell carcinoma;    Meta-analysis;   

DOI  :  10.1186/s12885-016-2535-3

 received in 2015-05-03, accepted in 2016-07-06,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundNumerous case–control studies have been performed to investigate the association between three cyclooxygenase-2 (COX-2) polymorphisms (rs20417 (−765G > C), rs689466 (−1195G > A), and rs5275 (8473 T > C)) and the risk of head and neck squamous cell carcinoma (HNSCC). However, the results were inconsistent. Therefore, we conducted this meta-analysis to investigate the association.MethodsWe searched in PubMed, Embase, and Web of Science up to January 20, 2015 (last updated on May 12, 2016). Two independent reviewers extracted the data. Odds ratios (ORs) with their 95 % confidence intervals (CIs) were used to assess the association. All statistical analyses were performed using the Review Manager (RevMan) 5.2 software.ResultsFinally 8 case–control studies were included in this meta-analysis. For unadjusted data, an association with increased risk was observed in three genetic models in COX-2 rs689466 polymorphism; however, COX-2 rs5275 and rs20417 polymorphisms were not related to HNSCC risk in this study. The pooled results from adjusted data all revealed non-significant association between these three polymorphisms and risk of HNSCC. We also found a similar result in the subgroup analyses, based on both unadjusted data and adjusted data.ConclusionCurrent results suggest that COX-2 rs689466, rs5275, and rs20417 polymorphisms are not associated with HNSCC. Further large and well-designed studies are necessary to validate this association.

【 授权许可】

CC BY   
© Leng et al. 2016