Modern extraction techniques and their impact on the pharmacological profile of Serenoa repens extracts for the treatment of lower urinary tract symptoms

BMC Urology

Review

Simone Carradori¹  Arianna Granese¹  Celeste De Monte¹  Costantino Leonardo²  Giovanni Battista Di Pierro²  Cosimo De Nunzio³ 

[1] Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy;Department of Obstetrics, Gynecology and Urology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy;Department of Urology, Ospedale Sant’Andrea, Sapienza University of Rome, Via di Grottarossa 1035/1039, 00189, Rome, Italy;

关键词: Benign prostatic hyperplasia;    Serenoa repens;    Extraction techniques;    Supercritical fluid extraction;    Lipidosterolic composition;    Content standardization;   

DOI  :  10.1186/1471-2490-14-63

 received in 2014-01-27, accepted in 2014-07-28,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundBioactive compounds from plants (i.e., Serenoa repens) are often used in medicine in the treatment of several pathologies, among which benign prostatic hyperplasia (BPH) associated to lower urinary tract symptoms (LUTS).DiscussionThere are different techniques of extraction, also used in combination, with the aim of enhancing the amount of the target molecules, gaining time and reducing waste of solvents. However, the qualitative and quantitative composition of the bioactives depends on the extractive process, and so the brands of the recovered products from the same plant are different in terms of clinical efficacy (no product interchangeability among different commercial brands).SummaryIn this review, we report on several and recent extraction techniques and their impact on the composition/biological activity of S. repens-based available products.

【 授权许可】

Unknown   
© De Monte et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.