Non-alcoholic and alcoholic Fatty Liver Disease - two Diseases of Affluence associated with the Metabolic Syndrome and Type 2 Diabetes: the FIN-D2D Survey

BMC Public Health

Research Article

Satu Männistö¹  Juha Saltevo²  Eeva Korpi-Hyövälti³  Hannele Yki-Järvinen⁴  Jaakko Tuomilehto⁵  Liisa Saarikoski⁶  Markku Peltonen⁶  Anna Kotronen⁷  Jouko Sundvall⁸  Timo Saaristo⁹  Heikki Oksa⁹ 

[1] Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland;Department of Internal Medicine, Central Finland Central Hospital, Jyväskylä, Finland;Department of Internal Medicine, South Ostrobothnia Central Hospital, Seinäjoki, Finland;Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland;Department of Public Health, University of Helsinki, Finland;Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland;Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland;Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland;Minerva Medical Research Institute, Helsinki, Finland;Laboratory of Analytical Biochemistry, Department of Health and Functional Capacity, National Institute for Health and Welfare, Helsinki, Finland;Tampere University Hospital, Tampere, Finland;

关键词: Metabolic Syndrome;    Oral Glucose Tolerance Test;    Proton Magnetic Resonance Spectroscopy;    Abnormal Glucose Tolerance;    High Alcohol Consumption;   

DOI  :  10.1186/1471-2458-10-237

 received in 2009-11-27, accepted in 2010-05-10,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundNon-alcoholic fatty liver disease (NAFLD) is known to be associated with the metabolic syndrome (MetS) and abnormal glucose tolerance. Whether alcoholic fatty liver disease (AFLD) is associated with similar metabolic abnormalities has not been examined in a population-based study. We aimed at assessing the prevalences of NAFLD and AFLD, and to examine to what extent these conditions are associated with MetS and abnormal glucose tolerance.MethodsThe cohort included 2766 Finnish subjects (45-74 years) from the population-based FIN-D2D survey. Features of insulin resistance, components of the MetS, glucose tolerance status by oral glucose tolerance test, serum liver enzyme concentrations, and daily alcohol consumption were assessed.ResultsSubjects with NAFLD and AFLD were equally obese and had similar fasting and insulin concentrations. The prevalences of NAFLD and AFLD were 21% (95% CI: 19%-22%) and 7% (95% CI: 6%-8%). The MetS was slightly more prevalent in AFLD (73%) than in NAFLD (70%, p = 0.028), and type 2 diabetes was similarly prevalent in NAFLD and AFLD (24-25%). The MetS and type 2 diabetes were more prevalent in subjects with NAFLD or AFLD compared to subjects with normal LFTs (53% and 14%, p < 0.0001 for both).Discussion and conclusionIn Finnish middle-aged population, the prevalence of NAFLD is 3-fold higher than that of AFLD. The prevalences of MetS and type 2 diabetes are, however, significantly increased in both NAFLD and AFLD compared to subjects with normal LFTs. Subjects with AFLD are thus similarly metabolically unhealthy as subjects with NAFLD.

【 授权许可】

CC BY   
© Kotronen et al; licensee BioMed Central Ltd. 2010