Correlation between short- and long-term effects of intravitreal ranibizumab therapy on macular edema after branch retinal vein occlusion: a prospective observational study

BMC Ophthalmology

Research Article

Akitoshi Yoshida¹  Taiji Nagaoka¹  Yoshiro Minami²  Akihiro Ishibazawa³ 

[1] Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan;Department of Ophthalmology, Nayoro City General Hospital, Nishi 7 Minami 8-1, 096-8511, Nayoro, Japan;Department of Ophthalmology, Nayoro City General Hospital, Nishi 7 Minami 8-1, 096-8511, Nayoro, Japan;Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan;

关键词: Branch retinal vein occlusion;    Macular edema;    Ranibizumab;   

DOI  :  10.1186/s12886-017-0485-4

 received in 2016-12-18, accepted in 2017-06-08,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe correlation between the short- and long-term effects of intravitreal ranibizumab (IVR) on macular edema after branch retinal vein occlusion (BRVO) remains unclear. We assessed the correlation between the short- and long-term effects of IVR on macular edema after BRVO.MethodsTwenty-one eyes with macular edema after BRVO were enrolled in this prospective observational study. We measured the foveal thickness (FT) and the best-corrected visual acuity (BCVA) before, 1 day after, and 1 month after IVR (0.5 mg) and then at least every 2 months thereafter until 6 months after the injection. If the macular edema recurred, another injection was administered. The primary endpoint was the change from baseline in the BCVA (ΔVA).ResultsThe mean logarithm of the minimum angle of resolution VA improved significantly (p = 0.01, p < 0.0001, respectively) after 1 day from 0.65 ± 0.28 to 0.51 ± 0.21 (20/89 to 20/63, Snellen equivalent) and after 6 months to 0.29 ± 0.24 (20/39, Snellen equivalent). The mean FT decreased significantly (p < 0.0001) after 1 day from 482 ± 85 μm to 349 ± 75 μm and after 6 months to 305 ± 84 μm. The 1-day VA was significantly (r = 0.68, p = 0.0007) positively correlated with the 6-month VA. The 1-day ΔVA was significantly (r = 0.79, p < 0.0001) positively correlated with the 6-month ΔVA.ConclusionsThe short-term effects of IVR may predict the long-term effects of IVR in macular edema secondary to BRVO.Trial registrationTrial registration number: UMIN000027003. Retrospectively registered. (April/15/2017)

【 授权许可】

CC BY   
© The Author(s). 2017