Regular physical activity and cardiovascular biomarkers in prevention of atherosclerosis in men: a 25-year prospective cohort study

BMC Cardiovascular Disorders

Research Article

Milena Orczykowska¹  Elżbieta Dziankowska-Zaborszczyk²  Tomasz Kostka³  Ewa Rębowska⁴  Magdalena Kwaśniewska⁴  Wojciech Drygas⁵  Anna Jegier⁶  Joanna Leszczyńska⁶ 

[1] Central Clinical Hospital, Medical University of Lodz, 92-213, Lodz, Poland;Department of Epidemiology and Biostatistics, Medical University of Lodz, Zeligowskiego 7/9, 90-752, Lodz, Poland;Department of Geriatrics, Medical University of Lodz, Lodz, Poland;Department of Preventive Medicine, Medical University of Lodz, Zeligowskiego 7/9, 90-752, Lodz, Poland;Department of Preventive Medicine, Medical University of Lodz, Zeligowskiego 7/9, 90-752, Lodz, Poland;Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, Institute of Cardiology, Warsaw, Poland;Department of Sports Medicine, Medical University of Lodz, 92-213, Lodz, Poland;

关键词: Physical Activity Level;    Coronary Artery Calcium;    Coronary Artery Calcium Score;    Subclinical Atherosclerosis;    Reactive Hyperemia Index;   

DOI  :  10.1186/s12872-016-0239-x

 received in 2015-09-30, accepted in 2016-03-28,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe purpose of the study was to examine the association between leisure-time physical activity (LTPA), cardiovascular biomarkers and atherosclerosis among asymptomatic men with stable LTPA level throughout the 25-year prospective observation.MethodsOut of 101 asymptomatic men prospectively observed for their lifestyle and cardiovascular risk factors, the cohort of 62 individuals (mean age 59.9 years) maintained a stable LTPA level during the 25-year observation. Regular check-ups with the assessment of traditional risk factors, detailed measurements of LTPA level and aerobic capacity were performed since baseline. At the latest follow-up (2011/12) a set of cardiovascular biomarkers was measured using enzyme-linked immunosorbent assay. Subclinical atherosclerosis was assessed by means of coronary artery calcification score and intima-media thickness (IMT). Endothelial function was evaluated by means of the reactive hyperemia index. The studied biomarkers and indices were analyzed in the three cohorts representing stable low-tomoderate (<2050 kcal/week), high (2050-3840 kcal/week) and very high LTPA (>3840 kcal/week).ResultsAt baseline the three cohorts were comparable in terms of age and clinical characteristics. At follow-up, the cohort with stable high LTPA (2050-3840 kcal/week) had significantly lower concentrations of hs-CRP (2.20 ± 1.0 mg/L), oxidized-LDL (68.35 ± 67.7 ng/mL), leptin (4.71 ± 3.07 ng/mL) and irisin (0.47 ± 0.13 μmol/L), and the most favorable indices of atherosclerosis and endothelial function as compared with other groups (p < 0.05). Regular marathon runners had increased concentrations of hsCRP (3.12 ± 1.4 mg/L), oxidized-LDL (249.8 ± 129 ng/ml), Interleukine-6 (3.74 ± 2.4 pg/ml). A positive correlation was observed between hsCRP and IMT (r = 0.301; p < 0.01), and irisin and IMT (r = 0.223; p < 0.05).ConclusionsThe data suggest that stable high LTPA (2050-3840 kcal/week) is associated with the most favorable profile of key cardiovascular biomarkers and indices of atherosclerosis. Lifetime very high LTPA is associated with increased lowgrade inflammation and may, therefore, exert an atherogenic effect.

【 授权许可】

CC BY   
© Kwaśniewska et al. 2016