Factors influencing treatment outcome in patients with gastroesophageal reflux disease: outcome of a prospective pragmatic trial in Asian patients

BMC Gastroenterology

Research Article

Hyojin Park¹  Bor-Shyang Sheu²  Jayaram Menon³  Myung-Gyu Choi⁴  Steven Mesenas⁵  Han-Chung Lien⁶  Justin CY Wu⁷  Tsai-Yuan Hsieh⁸  Khean Lee Goh⁹  Kee Don Choi^1,10  Hwoon-Yong Jung^1,10 

[1] Gangnam Severance Hospital, Seoul, Korea;National Cheng Kung University Hospital, Tainan, China;Queen Elizabeth Hospital, Kota Kinabalu, Malaysia;Seoul St Mary’s Hospital, Seoul, Korea;Singapore General Hospital, Singapore, Singapore;Taichung Veterans General Hospital, Taichung, China;The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China;Tri-Service General Hospital, Taipei, China;University of Malaya, Kuala Lumpur, Malaysia;University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea;

关键词: Pantoprazole;    Asian Patient;    Proton Pump Inhibitor Therapy;    Proton Pump Inhibitor Treatment;    Hospital Anxiety Depression Scale;   

DOI  :  10.1186/1471-230X-14-156

 received in 2013-06-14, accepted in 2014-08-08,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundPredicting response to proton pump inhibitor (PPI) treatment can aid the effective management of gastroesophageal reflux disease (GERD). The aim was to investigate the predictors of symptomatic response to pantoprazole in Asian patients with GERD; the first study of its kind in Asian patients.MethodsAsian patients with GERD symptoms (N = 209) received pantoprazole 40 mg daily for 8 weeks in a multinational, prospective, open-label study. Response was assessed using ReQuest™. Baseline and demographic factors were examined using logistic regression to determine if they were related to treatment response.ResultsResponse rates were 44.3% (Week 4) and 63.6% (Week 8) in Asian patients versus 60.7% (P < 0.001) and 72.2% (P = 0.010) for the rest of the world. Higher response rates at 8 weeks occurred in patients with erosive reflux disease (ERD; 71.3%) versus those with non-erosive reflux disease (NERD) at baseline (48.5%). The presence of ERD (P = 0.0143) and lower ReQuest™-GI scores at baseline (P = 0.0222) were associated with response. Improvements in quality of life (QoL) and anxiety and depression at 4 and 8 weeks were associated with treatment response (both P < 0.0001). Patient satisfaction correlated with treatment response (P < 0.0001), and improvement in anxiety and depression (P < 0.0001) and QoL (P < 0.0001).ConclusionsAsian patients with GERD, especially those with NERD, may have lower response rates to PPIs than Western populations. ERD and less severe gastrointestinal symptoms may help to predict symptomatic responses to PPIs in Asian patients.Trial RegistrationClinicalTrial.gov identifier: NCT00312806.

【 授权许可】

Unknown   
© Goh et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.