Corneal thickness, epithelial thickness and axial length differences in normal and high myopia

BMC Ophthalmology

Research Article

Qiang Wu¹  Xiaogang Wang²  Jing Dong³ 

[1] Affiliated Sixth People’s Hospital Shanghai Jiao Tong University, Shanghai, P.R. China;Shanxi Eye Hospital, Shanxi, P.R. China;The First Hospital of Shanxi Medical University, Shanxi, P.R. China;

关键词: Axial length;    Corneal thickness;    Epithelial thickness;    High myopia;    Optical coherence tomography;   

DOI  :  10.1186/s12886-015-0039-6

 received in 2015-01-10, accepted in 2015-04-29,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundCorneal biometric parameters can possibly be influenced by high myopia (HM). The influence of HM on corneal thickness (CT), epithelial thickness (ET) has not yet been clearly established. The aim of this study is to observe ET, CT and axial length (AL) differences between in normal and subjects with HMs and to investigate factors influencing the corneal biometric parameters and AL, such as age and gender.MethodsA total of 97 normal subjects (97 eyes) and 48 HM subjects (48 eyes) were included. The ET and CT of the central 6-mm diameter (17 regions) and the AL data were captured. The 17 corneal and epithelial regions were the center (1 mm radius, area a), the inner ring (2.5 mm radius, area b), the outer ring (3 mm radius, area c) and the 8 radial scan lines in eight directions (Superior (1) , SN (2), Nasal (3), IN (4), Inferior (5), IT (6), Temporal (7), ST (8)) with an angle of 45° between each consecutive scan line (a, b 1–8, c 1–8).ResultsThe ALs were increased about 4 mm in the HMs (P < 0.001). No differences in ET were observed; in contrast, significantly thicker CTs were observed in the HMs in 16 regions except the b5 subregion. In normal group, age was negatively correlated with AL but not CCT and CET and gender was correlated with CET. In HM group, age was not correlated with CCT , AL or CET and gender was correlated with AL and CCT but not CET.ConclusionsCT was thicker in the HMs but not ET. Age and gender should be considered for AL, CT and ET in both normal and HM group.

【 授权许可】

Unknown   
© Wang et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.