Recipient and donor thrombophilia and the risk of portal venous thrombosis and hepatic artery thrombosis in liver recipients

BMC Gastroenterology

Research Article

Carlos Jimenez¹  Enrique Moreno¹  Teresa Cedena²  Rosa Ayala³  Joaquín Martínez-López³  Carmen Ribera³  Rosalía Bustelos⁴ 

[1] General Surgery Alimentary Tract and Abdominal Organ Transplantation Department, 12 De Octubre University Hospital, Madrid, Spain;Complutense De Madrid University, Madrid, Spain;Hematology Department, 12 De Octubre University Hospital, Madrid, Spain;Hematology Department, 12 De Octubre University Hospital, Madrid, Spain;Complutense De Madrid University, Madrid, Spain;Hematology Department, Sureste Hospital (Arganda), Madrid, Spain;

关键词: Liver Transplantation;    Orthotopic Liver Transplant;    Biliary Atresia;    Thrombophilia;    Activate Partial Thromboplastin Time;   

DOI  :  10.1186/1471-230X-11-130

 received in 2011-07-20, accepted in 2011-11-28,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundVascular complications, such as HAT, are an important cause of graft loss and recipient mortality. We aimed to characterize post-transplant thrombotic events in a cohort of liver transplant recipients, and identify independent risk factors for these complications.MethodsWe conducted a thrombophilic study of 293 orthotopic liver transplants performed in the Digestive Surgery Department of the 12 de Octubre Hospital (Madrid, Spain) between January 2001 and December 2006.ResultsThe most frequent post-transplant thrombotic events were HAT (9%) and PVT (1.7%). The one variable associated with post-transplant thrombotic event was a high fibrinogen level in the global cohort of liver transplantation. But toxicity as event post-OLT has been associated with post-transplant thrombotic event in the retrospective group and high fibrinogen level and low protein C levels were associated post-transplant thrombotic event in the prospective group. Liver disease relapse (HR 6.609, p < 0.001), high levels of FVIII (HR 1.008, p = 0.019)) and low levels of antithrombin (HR 0.946, p < 0.001) were associated with poor overall survival (OS).In conclusion, high fibrinogen and decreased protein C levels were associated with allograft thrombosis. Further studies are required in order to assess the clinical relevance of these parameters in prospective studies and to study the effect of anticoagulation prophylaxis in this group of risk.

【 授权许可】

CC BY   
© Ayala et al; licensee BioMed Central Ltd. 2011