Duloxetine-induced rapid eye movement sleep behavior disorder: a case report

BMC Psychiatry

Case Report

Ye Zhang¹  Linghui Yang¹  Xiangdong Tang¹  Taomei Li¹  Lu Tan¹  Junying Zhou¹  Rong Ren¹ 

[1] Sleep Medicine Center, Laboratory of Anaesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China;

关键词: Duloxetine;    Rapid eye movement sleep behavior disorder;    Polysomnography;   

DOI  :  10.1186/s12888-017-1535-4

 received in 2017-07-20, accepted in 2017-11-09,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTricyclic antidepressants and selective serotonin reuptake inhibitors have been reported to induce the symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) or to exacerbate REM sleep without atonia. With this case report, we found an association between typical RBD and duloxetine, a serotonin-noradrenaline reuptake inhibitor.Case presentationWe present a case of a 62-year-old woman who experienced enactment behaviors with violent dreams that were associated with increased tonic or phasic chin electromyography activity during REM sleep after treated with duloxetine. RBD symptoms were gradually reduced and completely ceased after discontinuation of duloxetine for 37 days.ConclusionThe current case appears to be the first observation of duloxetine-induced RBD. We describe features of RBD induced by duloxetine that are similar and different from that induced by tricyclic antidepressants and selective serotonin reuptake inhibitors.

【 授权许可】

CC BY   
© The Author(s). 2017