Estimated birth weight and adult cardiovascular risk factors in a developing southern Chinese population: a cross sectional study

BMC Public Health

Research Article

WS Zhang¹  CQ Jiang¹  BJ Cowling²  CM Schooling²  TH Lam²  SL Au Yeung² 

[1] Guangzhou Number 12 Hospital, Guangzhou, China;School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China;

关键词: Birth Weight;    Instrumental Variable;    Cardiovascular Disease Risk Factor;    International Diabetes Federation Definition;    Birth Rank;   

DOI  :  10.1186/1471-2458-10-270

 received in 2010-01-12, accepted in 2010-05-24,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundBirth weight is negatively associated with cardiovascular diseases and diabetes, but the associations are less well-established in developing populations where birth weight is often unavailable. We studied the association of birth weight and cardiovascular risk, using birth rank as an instrumental variable, in Southern China.MethodsWe used published data on birth weight by birth rank from an appropriate population and baseline data from the Guangzhou Biobank Cohort Study phases 2 & 3 (2005-8) to examine the adjusted associations, using instrumental variable analysis, of birth weight with clinically measured cardiovascular risk factors and the metabolic syndrome in older (≥ 50 years) men (n = 5,051) and women (n = 13,907).ResultsEstimated birth weight was associated with lower blood pressure (systolic -0.25 mm Hg 95% confidence interval (CI), -0.53 to 0.03 and diastolic -0.33 mm Hg 95% CI -0.48 to -0.18 per standard deviation higher birth weight), but had little association with glucose, lipids, waist-hip ratio, body mass index or the metabolic syndrome, adjusted for age, sex, early environment and number of offspring.ConclusionBirth weight may impact blood pressure; however associations of birth weight with other cardiovascular risk factors may not be related to foetal exposures, but speculatively could be an historical co-incidence, with corresponding implications for prevention.

【 授权许可】

Unknown   
© Schooling et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.