BMC Nephrology | |
Transfusion burden in non-dialysis chronic kidney disease patients with persistent anemia treated in routine clinical practice: a retrospective observational study | |
Research Article | |
Jeffrey Petersen1  John M Brooks2  Jerry Yee3  Shravanthi R Gandra4  Ze Cong4  Lois Lamerato5  Kathleen M Fox6  | |
[1] Clinical Research, Amgen, Inc., 1 Amgen Center Drive, 91320, Thousand Oaks, CA, USA;College of Pharmacy, University of Iowa, 115 S. Grand Avenue, 52242, Iowa City, IA, USA;Division of Nephrology and Hypertension, Henry Ford Health System, 2799 W. Grand Blvd, 48202, Detroit, MI, USA;Global Health Economics, Amgen, Inc., 1 Amgen Center Drive, 91320, Thousand Oaks, CA, USA;Josephine Ford Cancer Center, Henry Ford Health System, 1 Ford Place Center, 48202, Detroit, MI, USA;Strategic Healthcare Solutions, LLC, P.O. Box 543, 21111, Monkton, MD, USA; | |
关键词: Chronic Kidney Disease; Index Date; Chronic Kidney Disease Patient; Veteran Health Administration; Severe Anemia; | |
DOI : 10.1186/1471-2369-13-5 | |
received in 2011-07-26, accepted in 2012-01-24, 发布年份 2012 | |
来源: Springer | |
【 摘 要 】
BackgroundTransfusion patterns are not well characterized in non-dialysis (ND) chronic kidney disease (CKD) patients. This study describes the proportion of patients transfused, units of blood transfused and trigger-hemoglobin (Hb) levels for transfusions in severe anemic, ND-CKD patients in routine practice.MethodsA retrospective cohort study of electronic medical record data from the Henry Ford Health System identified 374 adult, ND-CKD patients with severe anemia (Hb < 10 g/dL and subsequent use of erythropoiesis-stimulating agents [ESA] therapy, blood transfusions, or a second Hb < 10 g/dL) between January 2004 and June 2008. Exclusions included those with prior diagnoses of cancer, renal or liver transplant, end-stage renal disease, acute bleeding, trauma, sickle cell disease, or aplastic anemia. A gap of ≥ 1 days between units of blood transfused was counted as a separate transfusion.ResultsAt least 1 transfusion (mean of 2 units; range, 1-4) was administered to 20% (75/374) of ND-CKD patients with mean (± SD) follow-up of 459 (± 427) days. The mean (± SD) Hb level closest and prior to a transfusion was 8.8 (± 1.5) g/dL. Patients who were hospitalized in the 6 months prior to their first anemia diagnosis were 6.3 times more likely to receive a blood transfusion than patients who were not hospitalized (p < 0.0001). Patients with peripheral vascular disease (PVD) were twice as likely to have a transfusion as patients without PVD (p = 0.04).ConclusionsTransfusions were prevalent and the trigger hemoglobin concentration was approximately 9 g/dL among ND-CKD patients with anemia. To reduce the transfusion burden, clinicians should consider other anemia treatments including ESA therapy.
【 授权许可】
CC BY
© Fox et al; licensee BioMed Central Ltd. 2012
【 预 览 】
Files | Size | Format | View |
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RO202311093793263ZK.pdf | 471KB | download |
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