Fusarium ramigenum, a novel human opportunist in a patient with common variable immunodeficiency and cellular immune defects: case report

BMC Infectious Diseases

Case Report

G. Sybren de Hoog¹  Abdullah M. S. Al-Hatmi²  Mihai G. Netea³  Jacques F. Meis⁴  Valeriu Gheorghita⁵  Ruxandra V. Moroti⁶ 

[1] CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands;Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands;CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands;Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands;Directorate General of Health Services, Ibri Hospital, Ministry of Health, Muscat, Oman;Department of Internal Medicine, Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands;Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands;Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands;National Institute for Infectious Diseases “Prof.Dr.Matei Bals”, Bucharest, Romania;Carol Davila, Central Emergency University, Military Hospital, Bucharest, Romania;National Institute for Infectious Diseases “Prof.Dr.Matei Bals”, Bucharest, Romania;Carol Davila, University of Medicine and Pharmacology, Bucharest, Romania;

关键词: Fusarium ramigenum;    Immune deficiency;    Gamma-interferon;    IL-17 deficiency;   

DOI  :  10.1186/s12879-016-1382-9

 received in 2015-12-09, accepted in 2016-01-25,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundFusarium species are ubiquitous environmental fungi that occasionally provoke serious invasive infections in immunocompromised hosts. Among Fusarium species, Fusarium ramigenum, belonging to the Fusarium fujikuroi species complex, has thus far never been found to cause human infections. Here we describe the first case of invasive fusariosis caused by Fusarium ramigenum in a human and also identify immunological deficiencies that most likely contributed to invasiveness.Case presentationA 32-year-old Caucasian male with a seemingly insignificant medical history of mild respiratory illness during the preceding two years, developed invasive pulmonary fusariosis. Detailed immunological assessment revealed the presence of common variable immunodeficiency, complicated by a severe impairment of the capacity of T-cells to produce both gamma-interferon and interleukin-17. In-depth microbiological assessment identified the novel human opportunistic pathogen Fusarium ramigenum as cause of the infection.ConclusionThis report demonstrated that an opportunistic invasive fungal infection may indicate an underlying cellular immune impairment of the host. The unexpected invasive infection with Fusarium ramigenum in this case unmasked a complex combined humoral and cellular immunological deficiency.

【 授权许可】

CC BY   
© Moroti et al. 2016